Results 41 to 50 of about 5,454,379 (294)

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Urgent Biophilia: Green Space Visits in Wellington, New Zealand, during the COVID-19 Lockdowns

Land, 2022
Urgent biophilia describes the conscious desire of humans to seek interactions with nature during periods of stress. This study examines the changes in frequency and reason for visiting urban green spaces by residents of Wellington, New Zealand, to ...
Maggie MacKinnon, Rebecca MacKinnon, Maibritt Pedersen Zari, Kain Glensor, Tim Park   +4 more
doaj   +1 more source

Stress in fathers in the perinatal period: A systematic review

Midwifery, 2017
despite the evidence that fatherhood has a long-term positive and protective effect on men's health, there is also evidence that fatherhood in the perinatal period can be complex and demanding. Due to the potential increase in stressors in the perinatal period, there is reason to hypothesise that it is a time of increased stress for fathers.
Philpott, Lloyd F., Leahy-Warren, Patricia, Fitzgerald, Serena M., Savage, Eileen   +3 more
openaire   +3 more sources

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

Highly stressed: stressful and traumatic experiences among individuals with HIV/AIDS in the Deep South [PDF]

, 2011
A history of traumatic and/or stressful experiences is prevalent among HIV-infected individuals and has been consistently associated with poorer health outcomes.
Reif, Susan, Nathan Thielman, Raper, James, Kathryn Whetten, Jane Leserman, Susan Reif, James Raper, Michael Mugavero, Pence, Brian Wells, Mugavero, Michael, Leserman, Jane, Brian Wells Pence, Thielman, Nathan, Whetten, Kathryn   +13 more
core   +1 more source

Linking Stressful Life Events and Chronic Inflammation Using suPAR (Soluble Urokinase Plasminogen Activator Receptor)

, 2021
Stressful life events have been linked to declining health, and inflammation has been proposed as a physiological mechanism that might explain this association.
Harrington, HonaLee, Caspi, Avshalom, Harrington, Hona Lee, Poulton, Richie, Rasmussen, Line J. H., Eugen-Olsen, Jesper, Danese, Andrea, Houts, Renate, Bourassa, Kyle J., Ramrakha, Sandhya, Moffitt, Terrie E., Sugden, Karen, Rasmussen, Line J.H., Williams, Ben, Avshalom Caspi, Ben Williams, Terrie E. Moffitt, Renate Houts, Sandhya Ramrakha, Karen Sugden, HonaLee Harrington, Jesper Eugen-Olsen, Kyle J. Bourassa, Line J.H. Rasmussen, Richie Poulton, Andrea Danese   +25 more
core   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Psychosocial Risk Factors and Psychopathological Outcomes: Preliminary Findings in Italian Pregnant Women

Women, 2023
The perinatal period may represent a particularly challenging time for expecting parents. Previous studies have highlighted an association between several perinatal risk conditions (e.g., childhood maltreatment, poor social support, and stress levels ...
Maria Rita Infurna, Eleonora Bevacqua, Giulia Costanzo, Giorgio Falgares, Francesca Giannone   +4 more
doaj   +1 more source