Results 121 to 130 of about 489,418 (300)

Greater Work-Related Stress Among Chinese Media Workers in the Context of Media Transformation: Specific Stressors and Coping Strategies

International Journal of Communication, 2016
A steady rise in unexpected deaths of Chinese media workers from 2011 to 2015 highlights a new social problem. Content analysis of official reports about these deaths reveals the contribution of work-related stress and media transformation.
Min Wang, Zuosu Jiang
doaj  

Gender Analysis of Stress and Smoking Behavior: A Survey of Young Adults in Japan

Social Sciences
The global tobacco epidemic, claiming over 8 million lives annually, constitutes a formidable public health threat. Fatalities arise from both direct tobacco use and exposure to second-hand smoke.
Ayuka Yokoyama, Yuka Iwata, Nanami Oe, Etsuko Tadaka   +3 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Source of stressors and emotional disturbances among undergraduate science students in Malaysia

, 2014
Introduction: Higher education is considered as a stressful period in students’ life which they have to cope with since they are facing a variety of demands such as living away from their families, a heavily loaded curriculum, and inefficiency in both ...
Al-Ani, Ali Sabri Radeef, Ali, Syed Masroor, Faisal, Ghasak Ghazi, Mohamed Ismail, MaungKoHajee   +3 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Do Australian public and nonprofit nurses cope with administrative stressors? [PDF]

, 2011
The nursing profession in Australia and other OECD countries such as the USA and the UK, have focused on ways to recruit and retain nurses (e.g., Bartram, Joiner, & Stanton, 2004).
Chang, Esther, Teo, Stephen, Yeung, Melissa, Pick, David, Newton, Cameron J.   +4 more
core  

Hypothesis‐Driven Research on Multiple Stressors: An Analytical Framework for Stressor Interactions

Ecology and Evolution
ABSTRACT Identifying and characterizing stressor interactions is central to multiple stressor research. Such interactions refer to stronger (synergism) or weaker (antagonism) joint effects of co‐occurring stressors on biological entities, when compared to the predictions of a theoretical null model.
Madge Pimentel, I, Albini, D, Beermann, AJ, Leese, F, Macaulay, SJ, Matthaei, CD, Orr, JA, Piggott, JJ, Schäfer, RB   +8 more
openaire   +4 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source