Results 141 to 150 of about 5,378,814 (297)

Stretch-Induced Muscle Responses Under Threat Versus Safety. [PDF]

Eur J Neurosci
Visser YF, Bramson B, Medendorp WP, Roelofs K, Selen LPJ.   +4 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Cross-bridge model for predicting muscle short-range stiffness during movement. [PDF]

PLoS Comput Biol
van der Zee TJ, Simha SN, Milburn GN, Campbell KS, Ting LH, De Groote F.   +5 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Effects of strain rate and timing of ramp-stretch on temporal dynamics of the stress-response.

A) The average (±SEM) values for t12 (half-time of stress decay) are plotted against the time-to-stretch, following the load clamp, for a series of strain rates.
Bradley M. Palmer (18098423), Charles S. Chung (8909483), Bertrand C. W. Tanner (18098420)   +2 more
core   +1 more source

Self-Induced Stretch Syncope: An Underrecognized Condition. [PDF]

Ann Child Neurol Soc
Khan SM, Vedanarayanan VJ.
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Rate

, 2008
Fig.4 Comparison of loss rate using global SRM vs. ASRM 4 ASRM SRM
Loss Rate
core  

Discovering the mechanics of ultra-low density elastomeric foams in elite-level racing shoes. [PDF]

Eng Comput
McCulloch JA, Delp SL, Kuhl E.
europepmc   +1 more source