Results 31 to 40 of about 360,805 (290)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Effects of Neural Load on Hamstring Stretching upon Flexibility, Maximum Isometric Strength, and Tibial Nerve Pressure Pain Threshold in Healthy Subjects: A Randomized Clinical Trial

Applied Sciences
(1) Background: Stretching has been shown to improve flexibility, muscle activation, and coordination, but its effects may depend on neural tension during the stretch.
Carlos Fernández-del Rivero, Pablo García-Gil, Juan Mínguez-Cruz, Daniel Pecos-Martín, Samuel Fernández-Carnero, Alexander Achalandabaso-Ochoa, Daniel Rodríguez-Almagro   +6 more
doaj   +1 more source

Gastrocnemius Medialis Architectural Properties at Rest and During Stretching in Female Athletes with Different Flexibility Training Background

Sports, 2019
Background: This study examined gastrocnemius medialis (GM) architectural properties and ankle joint range of motion (ROM) between female athletes with different flexibility training background.
Olyvia Donti, Ioli Panidis, Gerasimos Terzis, Gregory C. Bogdanis   +3 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A Randomized and Blinded Study for the Treatment of Glenohumeral Internal Rotation Range of Motion Restriction: The Prone-Passive Stretching Technique

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers' Association, 2015
A Randomized and Blinded Study for the Treatment of Glenohumeral Internal Rotation Range of Motion Restriction: The Prone-Passive Stretching Technique Background: Prior research has focused on specific interventions to reduce the symptoms of ...
Dave Hammons, John W. McChesney, Michael Curtin, Ronald Pfeiffer, Keith Thiede   +4 more
doaj   +1 more source

Acute effects of static passive stretching without voluntary contraction of skeletal muscles on arterial stiffness in elderly lacking exercise habits

Journal of Physical Fitness and Sports Medicine, 2020
Stretching exercises conducted by oneself, herein referred to as self-stretching exercises, improve arterial stiffness in healthy people. Such exercises include voluntary contraction of peripheral muscles in addition to stretching of target muscles ...
Takeshi Morifuji, Hidetoshi Nakao, Masashi Hashimoto, Masakazu Imaoka, Hidemi Fujino   +4 more
doaj   +1 more source

Effects of Additional Radial Shock Wave Therapy on Spasticity of Upper Extremity Muscle

Surabaya Physical Medicine and Rehabilitation Journal, 2023
Background: Spasticity is one of the most common problems and greatly interferes with the functional capacity of chronic stroke patients. The most commonly used treatments are infrared therapy and stretching exercises, but they have not reduced ...
Go Linda Sugiarto, Tanti Ajoe Kesoema
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source