Results 281 to 290 of about 290,674 (330)

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

open access: yesChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel   +5 more
wiley   +1 more source

A Moratorium on Implantable Non-Medical Neurotech Until Effects on the Mind are Properly Understood. [PDF]

open access: yesNeuroethics
Bublitz C   +5 more
europepmc   +1 more source

Populism and policy capacity: Evidence from an opposition municipality in Istanbul

open access: yesPublic Administration and Development, EarlyView.
Abstract Despite achievements in its conceptual rigor, policy capacity still represents a relatively depoliticized concept that fails to sufficiently consider the ways in which politics plays a role in its creation, mobilization, or decay. This article seeks to contribute to this debate by investigating the impact of populism on policy capacity, the ...
Ebru Ertugal, Faik Gür, İnan Sevinç
wiley   +1 more source

Waste Reduction With Diabetes Devices: Barriers and Ways Ahead. [PDF]

open access: yesJ Diabetes Sci Technol
Hossmann S, Brandt D, Heinemann L.
europepmc   +1 more source

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