Results 91 to 100 of about 52,166 (266)

Stage-specific efficacy of pharmacological interventions on gait impairments in Parkinson’s disease

Frontiers in Neurology
ObjectiveThis study aims to clarify the variations and the therapeutic effects of medicine on gait by analyzing the gait characteristics before and after medication in various stages of Parkinson’s disease (PD).MethodsThis prospective study included 60 ...
Jun Zhang, Jun Zhang, Le Chen, Jun Li
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Thoracic limb stride length is associated with cognitive impairment in aging dogs

Frontiers in Veterinary Science
IntroductionChanges in stride length have been linked to cognitive impairment in humans with dementia. In aging dogs, cognitive decline is accompanied by slower gait speed.
Shaghayegh Rafatpanah Baigi, Akiya Stywall, Chin Chieh Yang, Alejandra Mondino, Gilad Fefer, Wojciech K. Panek, Katherine E. Simon, Beth C. Case, Margaret E. Gruen, Natasha J. Olby   +9 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Estimating Gait Speed in the Real World With a Head-Worn Inertial Sensor

IEEE Transactions on Neural Systems and Rehabilitation Engineering
Head-worn inertial sensors represent a valuable option to characterize gait in real-world conditions, thanks to the integration with glasses and hearing aids.
Paolo Tasca, Francesca Salis, Samanta Rosati, Gabriella Balestra, Claudia Mazza, Andrea Cereatti   +5 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Kinematic characteristics of the long jump approach run in paralympic-level male limb-deficients

European Journal of Human Movement, 2019
The purpose of this study was to define the variables typifying the long jump approach run phase in paralympic-level male amputees. The sample comprised of the eleven (4 transtibial, 5 transfemoral and 2 single below-the-knee amputees).
Josep María Padullés, Miguel Angel Torralba, José Luís López-del Amo, Marcelo Braz, Apostolos Theodorou, Xavier Padullés, Adrià García-Fresneda, Maria Luisa de Fuentes, Josefina Olsson, Vassilios Panoutsakopoulos   +9 more
doaj  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source