Results 51 to 60 of about 52,166 (266)

To STRIDE or not to STRIDE: a critique of “treat to target” in ulcerative colitis

Expert Review of Gastroenterology & Hepatology
The STRIDE consensus intends to complement the clinical endpoint with an endoscopic endpoint of mucosal healing and others as treatment targets in ulcerative colitis. If these targets are not reached, STRIDE requires dose or timing adjustments or switching the medication.
Klaus R, Herrlinger, Eduard F, Stange
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Increased temporal stride variability contributes to impaired gait coordination after stroke

Scientific Reports, 2022
Heightened motor variability is a prominent impairment after stroke. During walking, stroke survivors show increased spatial and temporal variability; however, the functional implications of increased gait variability are not well understood.
Prakruti Patel, Diana Enzastiga, Agostina Casamento-Moran, Evangelos A. Christou, Neha Lodha   +4 more
doaj   +1 more source

Adaptive Pedestrian Stride Estimation for Localization: From Multi-Gait Perspective

Sensors, 2022
Accurate and reliable stride length estimation modules play a significant role in Pedestrian Dead Reckoning (PDR) systems, but the accuracy of stride length calculation suffers from individual differences.
Chao Huang, Fuping Zhang, Zhengyi Xu, Jianming Wei   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Do humans optimally exploit redundancy to control step variability in walking? [PDF]

PLoS Computational Biology, 2010
It is widely accepted that humans and animals minimize energetic cost while walking. While such principles predict average behavior, they do not explain the variability observed in walking.
Jonathan B Dingwell, Joby John, Joseph P Cusumano   +2 more
doaj   +1 more source

The effect of stride frequency, stride length, and stride time on sprint patterns

Journal of Human Sport and Exercise
The research has been done to explain the complex interrelation of three important parameters of the sprinters-stride frequency, stride length, and step time-in the case of a national athlete HTY during the 100 meters sprint. Stride length refers to the distance covered in one complete step, while stride frequency is defined as the number of steps one ...
Mochamad Ridwan, Ainun Zulfikar Rizki, Vega Candra Dinata, Novadri Ayubi, Shoira Kubaeva   +4 more
openaire   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Characterization of Ash from Sugar Palm [Arenga Pinnata (Wrumb) Merr.] Fiber for Industrial Application

Journal of Natural Fibers, 2023
Sugar palm (Arenga Pinnata) fiber is abundant in Malaysia which necessitates its utilization as a source of agricultural waste for industrial development. This paper aims at characterizing the sugar palm fiber to explore its silica content as a potential
Isah Aliyu, Salit Mohd Sapuan, Edi Syams Zainudin, Umer Rashid, Mohd. Yusoff Mohamed Zuhri, Ridwan Yahaya   +5 more
doaj   +1 more source