Results 181 to 190 of about 1,327,280 (358)
Angewandte Chemie, EarlyView.An exception or the rule? This work represents a second observation, and the first crystallographic evidence, of true intercalation of a small‐molecule ligand (here, bisquinolinium PyDH2) into an antiparallel G‐quadruplex (G4) DNA fold. Abstract G‐quadruplexes (G4s) are non‐canonical DNA structures implicated in a number of biological processes.
Kailey N. Martin +7 more
wiley +2 more sources
The Quantum Physics of Black Holes: Results from String Theory [PDF]
, 2000 Sumit R. Das, Samir D. Mathur
openalex +1 more source
Parental Decision‐Making Following a Prenatal Diagnosis of Turner Syndrome: A Systematic Review
American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.ABSTRACT This systematic review investigates factors influencing parental decision‐making following a prenatal diagnosis (PND) of Turner syndrome (TS), aiming to enhance the foundation for tailored and supportive genetic counseling. A comprehensive literature search was conducted in the medical databases PubMed, Embase, and CINAHL.
Inger Lily Hjuler Dorf +2 more
wiley +1 more source
Mitigating Molecular Aggregation in Drug Discovery With Predictive Insights From Explainable AI
Angewandte Chemie, EarlyView.In this work, MEGAN, our explainable AI model, is applied to predict small colloidally aggregating molecules (SCAMs), a significant source of false positives in drug discovery. MEGAN provides interpretable predictions and proposes structurally similar, non‐aggregating alternative molecules.
Hunter Sturm +4 more
wiley +2 more sources
Interacting physical states of the bosonic string. II
Zeitschrift für Physik C Particles and Fields, 1990 A preliminary discussion on the importance of the contact terms in relation with the existence of many string vacua is presented. The problem of the BRST invariance of the string states transition amplitudes is considered in the sigma model approach to the string. It is shown that the BRST invariance is controlled by a gravitational (Diff) anomaly, and
openaire +4 more sources
Australian Journal of Social Issues, EarlyView.ABSTRACT Culturally and linguistically diverse (CALD) young people encounter unique circumstances, which can lead to high levels of distress. However, an up‐to‐date comprehensive literature review synthesising knowledge concerning mental health issues faced by CALD young people is lacking.
Abner Weng Cheong Poon +4 more
wiley +1 more source
Angewandte Chemie, EarlyView.Human H ferritin (HuHf) is a nanocarrier for anticancer metal drugs. By cryo‐EM, a 1.51 Å structure of its adduct with Au(NHC)Cl was solved, showing a novel tetranuclear gold(I) cluster bound to Cys90 and Cys102. Short inter‐metal distances indicate aurophilic interactions.
Lucrezia Cosottini +9 more
wiley +2 more sources
Animal Models and Experimental Medicine, EarlyView.In a study combining network pharmacological analysis and experimental verification, yunweiling has been shown improve functional constipation by inhibiting the PI3K‐Akt‐p53 signaling pathway and reducing the expression of TP53. Abstract Background This study investigated the impacts and mechanisms of yunweiling in the management of Functional ...
Peng Zhang +6 more
wiley +1 more source
Protein Secondary Structure Patterns in Short‐Range Cross‐Link Atlas
Angewandte Chemie, EarlyView.Short‐range cross‐linking mass spectrometry (XL‐MS) reveals secondary structure‐dependent patterns in proteome‐wide datasets. By integrating XL‐MS data with AlphaFold‐predicted structures, we introduce X‐SPAN, a novel validation metric that assesses data quality and enables pLDDT score benchmarking.
Alice Vetrano +6 more
wiley +2 more sources