Results 91 to 100 of about 616,096 (295)

A Proof‐of‐Concept Assessment of a Novel Wearable Eyelid Muscle Device: A Pre‐Clinical Animal Cadaver Study for Eyelid Closure Restoration

open access: yesAdvanced Robotics Research, EarlyView.
This article introduces a soft wearable eyelid sling device incorporating a hydraulic soft artificial muscle (SAM) for achieving complete closure of an eyelid. The SAM is driven by a cam mechanism that provides a displacement profile closely matched with those of a healthy eyelid.
Patrick Pruscino   +7 more
wiley   +1 more source

Energy Symmetry Breaking of Dirac and Weyl Fermions in Magnetized Spinning Conical Geometries

open access: yesAdvanced Theory and Simulations, EarlyView.
Exact solutions for relativistic fermions in magnetized, spinning conical geometries reveal defect‐induced symmetry breaking between fermion and antifermion energies. Energy levels depend on the magnetic field, background geometry, and fractionalized spin. When the defect's spin dominates, quantum effects diminish.
Abdullah Guvendi, Omar Mustafa
wiley   +1 more source

NAD+‐Boosters Improve Mitochondria Quality Control In Parkinson's Disease Models Via Mitochondrial UPR

open access: yesAdvanced Science, EarlyView.
Treatment of MPTP‐incubated cells with NAD+‐boosters increase the UPRmt/mitophagy‐related mitochondria quality control (MQC). Disturbed plasma UPRmt‐mitophagy‐mediated MQC profiles in PD patient samples. NMN inhibits motor deficit and forestalls neuropathology phenotypes of PD mice, which is required the atf4‐medicated UPRmt pathway.
Shuoting Zhou   +16 more
wiley   +1 more source

Inflationary string theory? [PDF]

open access: yesPramana, 2004
The inflationary paradigm provides a robust description of the peculiar initial conditions which are required for the success of the Hot Big Bang model of cosmology, as well as of the recent precision measurements of temperature fluctuations within the cosmic microwave background. Furthermore, the success of this description indicates that inflation is
openaire   +3 more sources

Branched‐Chain α Keto‐Acid Dehydrogenase Kinase‐Mediated AKT Phosphorylation Promotes RCC Tumorigenesis and Drug Resistance

open access: yesAdvanced Science, EarlyView.
This study identifies a novel oncogenic role and a previously unrecognized phosphorylation substrate of BCKDK in RCC, wherein it promotes tumor progression and drug resistance through AKT phosphorylation at both Thr308 and Ser473 sites and activation of AKT/mTOR and AKT/ABCB1 signaling pathways, offering a promising prognostic marker and therapeutic ...
Qin Tian   +18 more
wiley   +1 more source

Introduction to string theory

open access: yesSciPost Physics Lecture Notes
These are lecture notes of the introductory String Theory course held by one of the authors for the master program of Theoretical Physics at Turin University. The world-sheet approach to String Theory is pedagogically introduced in the framework of the bosonic string and of the superstring.
Maccaferri, Carlo   +2 more
openaire   +3 more sources

USP10 Inhibits Ferroptosis via Deubiquinating POLR2A in Head and Neck Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
This study identifies USP10 as a novel deubiquitinase that antagonizes ferroptosis in head and neck squamous cell carcinoma (HNSCC). Mechanistically, USP10 directly stabilizes POLR2A protein through post‐translational deubiquitination, enabling POLR2A‐mediated transcriptional activation of SLC7A11, a key ferroptosis inhibitor.
Diekuo Zhang   +13 more
wiley   +1 more source

Topics in String Theory and Quantum Gravity

open access: yes, 1992
These are the lecture notes for the Les Houches Summer School on Quantum Gravity held in July 1992. The notes present some general critical assessment of other (non-string) approaches to quantum gravity, and a selected set of topics concerning what we ...
Alvarez-Gaume, L., Vazquez-Mozo, M. A.
core  

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