Results 91 to 100 of about 43,429 (313)

Non-Riemannian geometry of M-theory

open access: yesJournal of High Energy Physics, 2019
We construct a background for M-theory that is moduli free. This background is then shown to be related to a topological phase of the E8(8) exceptional field theory (ExFT).
David S. Berman   +2 more
doaj   +1 more source

A Proof‐of‐Concept Assessment of a Novel Wearable Eyelid Muscle Device: A Pre‐Clinical Animal Cadaver Study for Eyelid Closure Restoration

open access: yesAdvanced Robotics Research, EarlyView.
This article introduces a soft wearable eyelid sling device incorporating a hydraulic soft artificial muscle (SAM) for achieving complete closure of an eyelid. The SAM is driven by a cam mechanism that provides a displacement profile closely matched with those of a healthy eyelid.
Patrick Pruscino   +7 more
wiley   +1 more source

Two-loop scattering amplitudes: double-forward limit and colour-kinematics duality

open access: yesJournal of High Energy Physics, 2019
We propose new formulae for the two-loop n-point D-dimensional integrands of scattering amplitudes in Yang-Mills theory and gravity. The loop integrands are written as a double-forward limit of tree-level trivalent diagrams, and are inferred from the ...
Yvonne Geyer   +2 more
doaj   +1 more source

Symmetry TFTs from String Theory. [PDF]

open access: yesCommun Math Phys, 2023
Apruzzi F   +4 more
europepmc   +1 more source

Phase‐Separation of YAP Mediates AJUBA Super Enhancer Activation to Promote Aberrant Mitosis in Breast Cancer

open access: yesAdvanced Science, EarlyView.
YAP undergoes phase separation to activate the AJUBA super‐enhancer, driving aberrant mitosis through spindle checkpoint dysregulation in breast cancer. This study uncovers a mechanistic link between YAP condensates, super‐enhancer activation, and aneuploidy formation.
Rui Zhang   +8 more
wiley   +1 more source

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

open access: yesAdvanced Science, EarlyView.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo   +6 more
wiley   +1 more source

Genome‐Wide by Lifetime Environment Interaction Studies of Brain Imaging Phenotypes

open access: yesAdvanced Science, EarlyView.
This study explores genome‐wide by lifetime environment interactions on brain imaging phenotypes. Gene‐environment interactions explain more phenotypic variance than main effects, pinpoint regulatory variants, and reveal exposure‐specific biological pathways.
Sijia Wang   +51 more
wiley   +1 more source

Inflationary string theory? [PDF]

open access: yesPramana, 2004
The inflationary paradigm provides a robust description of the peculiar initial conditions which are required for the success of the Hot Big Bang model of cosmology, as well as of the recent precision measurements of temperature fluctuations within the cosmic microwave background. Furthermore, the success of this description indicates that inflation is
openaire   +2 more sources

Cancer Immunotherapy via Disruption of Integrin αvβ3 and CD47 Costabilization on Cancer Cell Surface

open access: yesAdvanced Science, EarlyView.
This study identifies a cancer‐specific interaction between CD47 and integrin αvβ3 that facilitates immune evasion. A rationally designed peptide, PSFL‐NK13, disrupts this axis, enhancing macrophage‐mediated phagocytosis and suppressing tumor growth without inducing anemia.
Peng‐Cheng Yu   +12 more
wiley   +1 more source

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