Results 41 to 50 of about 39,454 (347)

Análisis de la capacidad de soporte sísmica de fundaciones superficiales [PDF]

open access: yes, 2014
Indexación: Web of Science; Scielo.In the context of engineering practice, the problem of the seismic bearing capacity of shallow foundations has been solved indirectly, either due an increase of the static allowable soil pressures related to the ...
Paillao V., Danilo   +1 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Bearing Capacity of A Strip Footing Resting On Treated And Untreated Soils [PDF]

open access: yes, 2014
Expansive soils are highly susceptible to volumetric changes leading to rapid loss in the bearing capacity of footings resting on them. Among several techniques available to treat expansive soils, lime or fly ash stabilization gained prominence during ...
B, Umashankar   +3 more
core  

Fluidity Onset in Graphene [PDF]

open access: yes, 2018
Viscous electron fluids have emerged recently as a new paradigm of strongly-correlated electron transport in solids. Here we report on a direct observation of the transition to this long-sought-for state of matter in a high-mobility electron system in ...
Bandurin, Denis A.   +8 more
core   +3 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Estimation of Bearing Capacity of Strip Footing Rested on Bilayered Soil Profile Using FEM-AI-Coupled Techniques

open access: yesAdvances in Civil Engineering, 2022
In this research work, finite element method (FEM) and 2D Plaxis were employed to generate numerical values for bilayered soils bearing a strip footing of width B and depths, h and H, in order to predict the ultimate bearing capacity (UBC) of the strip ...
Ahmed M. Ebid   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Local Maximum Entropy Shape Functions Based FE-EFGM Coupling [PDF]

open access: yes, 2013
In this paper, a new method for coupling the finite element method (FEM)and the element-free Galerkin method (EFGM) is proposed for linear elastic and geometrically nonlinear problems using local maximum entropy shape functions in theEFG zone of the ...
Augarde, C.E., Coombs, W. M., Ullah, Z.
core  

Stabilized material point methods for coupled large deformation and fluid flow in porous materials

open access: yes, 2019
The material point method (MPM) has been increasingly used for the simulation of large deformation processes in fluid-infiltrated porous materials. For undrained poromechanical problems, however, standard MPMs are numerically unstable because they use ...
Choo, Jinhyun, Zhao, Yidong
core   +2 more sources

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