Results 51 to 60 of about 39,454 (347)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Estimation of ultimate bearing capacity of strip footings on cohesive-frictional soils using non-linear shear strength model

Tạp chí Khoa học và Công nghệ
This study widely investigated the applicability of the ultimate bearing capacity formula from the Architectural Institute of Japan (AIJ) while considering the effect of footing width.
Pham Ngoc Quang, Pham Ngoc Vinh
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

FINITE ELEMENT ANALYSIS OF STRIP FOOTING RESTING ON GIBSON-TYPE SOIL BY USING MATLAB

Journal of Engineering, 2011
This research presents a method of using MATLAB in analyzing a nonhomogeneous soil (Gibson-type) by estimating the displacements and stresses under the strip footing during applied incremental loading sequences.
Ahmed Qasim Obaid, Firas Hussain Ali, Adnan Qahtan Mohammed   +2 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Soil im

Alexandria Engineering Journal, 2016
Experimental and theoretical investigations are carried out on a strip-footing resting on laterally confined subgrade by vertical grouted diaphragm wall as a vertical reinforced element.
A.Z. Elwakil, W.R. Azzam
doaj   +1 more source

Behavior of Partially Saturated Cohesive Soil under Strip Footing

Journal of Engineering, 2023
In this paper, a shallow foundation (strip footing), 1 m in width is assumed to be constructed on fully saturated and partially saturated Iraqi soils, and analyzed by finite element method. A procedure is proposed to define the H – modulus function from
Mohammed Yousif Fattah, Mahmood Diab Ahmed, Hadeel Ammar Mohammed   +2 more
doaj   +1 more source

Densely distributed and real-time scour hole monitoring using piezoelectric rod sensors [PDF]

, 2019
This study aims to validate a piezoelectric driven-rod scour monitoring system that can sense changes in scour depth along the entire rod at its instrumented location.
Funderburk, Morgan L, Huang, Shieh-Kung, Loh, Chin-Hsiung, Loh, Kenneth J   +3 more
core  

Geotechnical design with apparent seismic safety factors well-bellow 1 [PDF]

, 2014
The paper demonstrates that whereas often in seismic geotechnical design it is not realistically feasible to design with ample factor of safety against failure as is done in static design, an "engineering" apparent seismic factor of safety less than 1 ...
Anastasopoulos, Apostolou, Chen, Chopra, Cremer, Drosos, Evangelia Garini, Gajan, Garini, Gazetas, Gazetas, Gelagoti, George Gazetas, Gerolymos, Harden, Ioannis Anastasopoulos, Makris, Mergos, Newmark, Panagiotidou, Paolucci, Priestley, Priestley, Sarma, Shirato, Taylor, Villaverde, Zhang   +27 more
core   +3 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source