Results 191 to 200 of about 20,903 (219)

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Superstitious conditioning shapes the illusory experience of free will under causal determinism. [PDF]

Front Hum Neurosci
Kansala C, Cicek E, Nkansah-Okoree VB, Golding AW, Murugan NJ, Rouleau N.   +5 more
europepmc   +1 more source

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Flapping-wing robot achieves bird-style self-takeoff by adopting reconfigurable mechanisms. [PDF]

Sci Adv
Chen A, Song B, Liu K, Wang Z, Xue D, Qi H.   +5 more
europepmc   +1 more source

Analysis of hybrid fractional integro-differential equations with application to cholera dynamics. [PDF]

Sci Rep
Algolam MS, Chebab M, Abdo MS, Alshammari F, Aldwoah K.   +4 more
europepmc   +1 more source

Probing the Hybrid σ/π-Holes in sp²-Hybridized Chalcogen Bond Donors and their Complexes with Ammonia. [PDF]

Chemphyschem
French KA, Devore DP, Ellington TL, Shuford KL.   +3 more
europepmc   +1 more source

Easy Prestressing of FRP for Strengthening RC Beams: Experimental Study with an Analytical Approach. [PDF]

Polymers (Basel)
Sakar G, Celik HK.
europepmc   +1 more source

Mesoscopic Quantum Effect: The Interaction of Electron Phenomena at the Mesoscopic Scale. [PDF]

Nanomaterials (Basel)
Chen K, Liu L.
europepmc   +1 more source

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Added resistance using Salvesen–Tuck–Faltinsen strip theory and the Kochin function

Applied Ocean Research, 2021
Mostafa Amini-Afshar, Harry B Bingham
exaly