AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells
Decreased sensitivity to AAV vector transduction in the outer hair cells (OHCs) of adult mice is primarily attributed to reduction of AAVR (Kiaa0319l; Au040320). Knockout of AAVR reduces AAV vector transduction efficiency in both inner hair cells (IHCs) and OHCs in neonatal mice.
Fan Wu+8 more
wiley +1 more source
Current Snapshots on Stroke Prevention and Control and More Proactive National Strategies Against It in China. [PDF]
Jiang B.
europepmc +1 more source
Sturge‐Weber syndrome (SWS) is characterized by leptomeningeal vascular malformations, leading to seizures and stroke. Analysis of 119 446 brain cells from SWS patients uncovered distinct cell heterogeneity and identified an EDN3⁺ meningeal fibroblast cluster, with WNT5A emerging as a potential key driver of SWS progression and a promising therapeutic ...
Daosheng Ai+14 more
wiley +1 more source
Exploring the occurence and risk factors of post-stroke depression among stroke survivors in Africa: a comprehensive systematic review and meta-analysis. [PDF]
Tinsae T+10 more
europepmc +1 more source
Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization
This study shows that macrophage interferon regulatory factor 4 (IRF4) improved arterial injury‐induced neointimal hyperplasia by promoting of M2 polarization via up‐regulating krüppel‐like factor 4 (KLF4) in rodent and nonhuman primate models. Notably, artesunate is identified as a potent inducer of IRF4 in macrophages, and proposed as a promising ...
Jinlin Miao+15 more
wiley +1 more source
Stroke attributed to kidney dysfunction from 1990 to 2021 and the prediction for 2040: an analysis of national data in China based on the Global Burden of Disease 2021 database. [PDF]
Guo N+7 more
europepmc +1 more source
A letter communicated from Mr. Thoresby F. R. S. to John Evelyn Esquire, concerning the cures done by Mr. Greatrix the stroker [PDF]
Valentine Greatrakes
openalex +1 more source
sEVs have a critical role in orchestrating interorgan crosstalk and mediating exercise‐induced therapeutic effects. Lin et al. demonstrates that sEVs miR‐17/20a‐5p mediates the muscle‐brain crosstalk and emphasizes the central role of mTOR signaling in executing molecular programs that can protect brain health in response to exercise. Abstract Physical
Huawei Lin+21 more
wiley +1 more source
Recurrent stroke in patients with history of stroke/transient ischemic attack and device-detected atrial fibrillation: A systematic review and meta-analysis. [PDF]
Palaiodimou L+16 more
europepmc +1 more source