Results 61 to 70 of about 5,496,574 (258)

Higher prehospital priority level of stroke improves thrombolysis frequency and time to stroke unit : the Hyper Acute STroke Alarm (HASTA) study

, 2012
BACKGROUND AND PURPOSE: Early initiated treatment of stroke increases the chances of a good recovery. This randomized controlled study evaluates how an increased priority level for patients with stroke, from level 2 to 1, from the Emergency Medical ...
von Arbin, Magnus,, Höjeberg, Bo,, Käll, Tor-Björn,, Mjörnheim, Susanna,, Engerström, Lars,, Berglund, Annika,, Sjöstrand, Christina,, von Euler, Mia,, Engqvist, Ann,, Wahlgren, Nils,, Svensson, Leif,, Sjostrand, C, von, Euler M,, von, Arbin M, Berglund, A,, Engerstrom, L, Kall, T-B, Svensson, L,, Wahlgren, N, Hojeberg, B, Mjornheim, S   +20 more
core   +1 more source

Glial and axonal body fluid biomarkers are related to infarct volume, severity, and outcome. [PDF]

, 2008
Body fluid biomarkers of central nervous system damage may help improve the prognostic and diagnostic accuracy in ischemic stroke. We studied 53 patients.
Stock, M, Michel, P, Schluep, M, Petzold, A, Petzold, A., Schluep, M., Michel, P., Stock, M.   +7 more
core   +1 more source

Mechanical Thrombectomy in Acute Stroke Patients with Moderate to Severe Pre-Stroke Disability

, 2022
BACKGROUND AND PURPOSE: Studies on mechanical thrombectomy (MT) in acute ischemic stroke (AIS) patients with preexisting disability are limited. We aimed to compare the outcomes of MT versus best medical treatment (BMT) in these patients. METHODS: In the
Gattringer, T., Sykora, M., Strambo, D., Neumann, Christian, Strambo, Davide, Deutschmann, H., Gattringer, Thomas, Mikšová, D., Krebs, Stefan, Lang, Wilfried, Ferrari, J., Deutschmann, Hannes, Posekany, Alexandra, Michel, Patrik, Posekany, A., Ferrari, Julia, Mikšová, Dominika, Hermann, Konstantin, Neumann, C., Sykora, Marek, Lang, W., Krebs, S., Gizewski, Elke, Hermann, K., Gizewski, E., Michel, P.   +25 more
core   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Management of acute stroke in patients taking novel oral anticoagulants

, 2014
Each year, 1 center dot 0-2 center dot 0% of individuals with atrial fibrillation and 0 center dot 1-0 center dot 2% of those with venous thromboembolism who are receiving one of the novel oral anticoagulants (dabigatran, rivaroxaban, or apixaban) can be
Steiner, Thorsten, Norrving, Bo, Hacke, Werner, Hankey, Graeme J., Lund University., Norrving, Bo,   +5 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Stroke prevalence in a poor neighbourhood of Sao Paulo, Brazil: applying a stroke symptom questionnaire

, 2011
Background Brazil has one of the highest stroke mortality rates in the world, these rates are most endemic in the poor. We verified the prevalence of stroke in a deprived neighbourhood in the city of Sao Paulo, Brazil and compared it with other surveys ...
BENSENOR, Isabela M., Paulo A. Lotufo, LOTUFO, Paulo A., Isabela M. Benseñor, GOULART, Alessandra C., ABE, Ivana M., Ivana M. Abe, Alessandra C. Goulart   +7 more
core   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source