Results 61 to 70 of about 512,398 (262)

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Quick and effective improvement of leucine enriched dietary supplement on malnutrition in acute stroke patients receiving enteral tube feeding

BMC Emergency Medicine, 2020
Background Malnutrition often occurs in acute stroke patients receiving enteral tube feeding (ETF). Unless malnutrition is improved, their clinical outcome is poor.
Takahisa Mori, Kazuhiro Yoshioka
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Anti-inflammatory Effect of Batroxobin Combined With Anticoagulation in Patients With Cerebral Venous Thrombosis

Clinical and Applied Thrombosis/Hemostasis
Inflammation is pivotal in the pathogenesis and development of cerebral venous thrombosis (CVT). Herein, we aimed to assess the anti-inflammatory effects of batroxobin combined with anticoagulation in CVT.
Duo Lan PhD, Xiaoming Zhang MD, Xiangqian Huang MD, Jingrun Li MD, Jiahao Song MD, Da Zhou PhD, Ran Meng MD, PhD   +6 more
doaj   +1 more source

Volume and Location Analysis of Intracerebral Hemorrhage for the Appropriate Use of Andexanet Alfa

Neurologia Medico-Chirurgica
Andexanet alfa was approved as a reversal agent for Factor Xa inhibitors in patients with uncontrolled or life-threatening bleeding, such as intracerebral hemorrhage. However, its use in cases of small hemorrhages remains controversial.
Takeru UMEMURA, Taketo HATANO, Yu ABEKURA, Takeshi MIYATA, Yuji AGAWA, Tomoya OGAWA, Takao MORITA, Wataru YOSHIZAKI, Takashi NAGAHORI, Koki MITANI, Ryo HAMAMOTO, Yusuke NAKAZAWA, Yukiko INAMORI, Wataru SHIRAISHI   +13 more
doaj   +1 more source

The Imperative to Develop Dedicated Stroke Centers

JAMA, 2000
OLDER PRACTITIONERS (INCLUDING ONE OF THE AUthors of this Editorial) will recall the days when patients with stroke were either treated at home or admitted to the hospital for compassionate observation. Neurologists made efforts to localize lesions and confirm functional areas of the brain and brainstem and described many vascular syndromes.
Barnett, H, Buchan, A
openaire   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Efficacy and Safety of the Individual Batroxobin Strategy in Treating Cerebral Venous Thrombosis: An Obstervational Study

Clinical and Applied Thrombosis/Hemostasis
Background Previous studies have demonstrated the potential benefits of the routine use of batroxobin in treating cerebral venous thrombosis (CVT).
Duo Lan MD, PhD, Xiangqian Huang MD, Xiaoming Zhang MD, Rong Wang MD, Mengqi Wang MD, PhD, Zhongao Wang MD, PhD, Yibing Guo MD, Da Zhou MD, PhD, Ran Meng MD, PhD   +8 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source