Results 91 to 100 of about 530,051 (308)

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Pediatric Stroke: A Single-Center Experience

Journal of Pediatric Hematology/Oncology, 2019
The aim of this study was to evaluate the clinical characteristics, risk factors, treatment, and outcomes of pediatric stroke cases. A total of 118 patients diagnosed with arterial ischemic stroke (AIS), hemorrhagic stroke, and sinovenous thrombosis (SVT) between January 2000 and December 2011 were included. Neonatal cases were excluded.
Söbü, Elif, Özdemir, Nihal, Uysal, Serap, Buyru, Nur, Celkan, Tiraje   +4 more
openaire   +2 more sources

Location‐Specific Hematoma Volume Predicts Early Neurological Deterioration in Supratentorial ICH

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Early neurological deterioration (END) adversely affects outcomes in patients with intracerebral hemorrhage (ICH). This study aimed to determine the location‐specific hematoma volumes for END in supratentorial ICH patients. Methods We retrospectively analyzed supratentorial ICH patients presenting from two prospective cohorts.
Zuoqiao Li, Guilin Meng, Zijie Wang, Xiao Hu, Jing Cheng, Chu Chen, Tiannan Yang, Jiaxin Luo, Zizhen Meng, Xueyun Liu, Qi Li   +10 more
wiley   +1 more source

Organization of stroke care in Turkey

, 2017
Stroke is one of the major health problems in Turkey. Since cerebrovascular disease is the second leading cause of death, institutional organizations are important to decrease the burden of stroke in our country.
Necioglu, Dilek, Ince, Birsen
core   +1 more source

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan, Mustafa Subhi, Elaina Luskin, Bryan Quah, Sreekanth Madhusoodhanan Nair, Arzu C. Has Silemek, Gabriela Zabala, Yujie Cui, Laura Locke, Paula Barreras, Marwa Kaisey, Vinicius Calsavara, Daniel S. Reich, Nancy L. Sicotte, Pascal Sati, Omar Al‐Louzi   +17 more
wiley   +1 more source

Big Data Approaches to Phenotyping Acute Ischemic Stroke Using Automated Lesion Segmentation of Multi-Center Magnetic Resonance Imaging Data

, 2019
Background and Purpose- We evaluated deep learning algorithms' segmentation of acute ischemic lesions on heterogeneous multi-center clinical diffusion-weighted magnetic resonance imaging (MRI) data sets and explored the potential role of this tool for ...
Lorentzen, Eric, Slowik, Agnieszka, Xu, Huichun,, Thijs, Vincent,, Kamnitsas, K, Mitchell, BD, Lorentzen, Eric,, Hancock, Brandon L., Rost, Natalia S., McArdle, Patrick F., MRI-Genetics Interface Exploration (MRI-GENIE), Hancock, Brandon L,, Rost, Natalia S,, Stanne, Tara M, Jern, Christina, Winzeck, S, Slowik, Agnieszka,, Mitchell, Braxton D., Schmidt, R, Mitchell, Braxton D,, Etherton, Mark R., Jiménez-Conde, Jordi,, McArdle, Patrick F,, Etherton, Mark R,, Xu, H, Winzeck, Stefan,, Vagal, Achala, Rost, NS, Sharma, Pankaj, Schirmer, Markus D., Sacco, Ralph L,, Rosand, Jonathan, Sacco, Ralph L., Schirmer, Markus D,, Worrall, Bradford B, Sacco, Ralph L, Sharma, P, Wasselius, Johan,, Bevan, Stephen,, Etherton, MR, Worrall, Bradford B,, Lemmens, R, Rosand, Jonathan,, Lund University., Donahue, K, Bouts, Mark J R J, Worrall, BB, Jern, C, Lindgren, Arne G,, McIntosh, Elissa C, Donahue, Kathleen, Lindgren, Arne G., Kittner, Steven J, Giese, Anne-Katrin,, Schirmer, MD, Mocking, Steven J T,, Bezerra, Raquel,, Hancock, BL, Xu, Huichun, Schmidt, Reinhold,, Giese, AK, Wu, O, Kittner, SJ, Rundek, T, Slowik, A, Kamnitsas, Konstantinos,, Kittner, Steven J,, Kittner, Steven J., Meschia, James F, Mocking, Steven J T, Irie, Robert E, Schmidt, Reinhold, Bouts, Mark J.RJ., Wu, Ona, Roquer, J, Roquer, Jaume,, Sharma, Pankaj,, Bouts, MJRJ, Jiménez-Conde, Jordi, Rost, Natalia S, Stanne, TM, Holmegaard, Lukas,, Schirmer, Markus D, Bouts, Mark J R J,, Roquer, Jaume, Donahue, Kathleen,, Frid, P, Lorentzen, E, McArdle, Patrick F, Holmegaard, L, Jern, Christina,, Rundek, Tatjana, Słowik, Agnieszka, Lindgren, Arne G, McIntosh, Elissa C., McIntosh, Elissa C,, Bouts, Mark J.R.J., Meschia, JF, Frid, Petrea, Wu, Ona,, Sacco, RL, Irie, Robert E., Bezerra, Raquel, Thijs, Vincent, Irie, Robert E,, Cole, John W, Jiménez-Conde, J, Genetics of Ischaemic Stroke Functional Outcome (GISCOME) Network, Bevan, S, Jane Maguire,, Jane Maguire, McIntosh, EC, Woo, D, Irie, RE, Hancock, Brandon L, Worrall, Bradford B., Mitchell, Braxton D, Mocking, Steven J.T., Maguire, Jane,, Maguire, Jane, Mocking, SJT, Kamnitsas, Konstantinos, McArdle, PF, Lemmens, Robin, Giese, Anne-Katrin, Wasselius, Johan, Cole, John W., Cole, John W,, Stanne, Tara M,, Bezerra, R, Rundek, Tatjana,, Stanne, Tara M., Maguire, J, Woo, Daniel, Thijs, V, Rosand, J, Holmegaard, Lukas, Bevan, Stephen, Vagal, A, Wasselius, J, Lemmens, Robin,, Meschia, James F., Lindgren, AG, Meschia, James F,, Etherton, Mark R, Woo, Daniel,, Cole, JW, Vagal, Achala,, Winzeck, Stefan, Frid, Petrea,   +148 more
core   +2 more sources

Stroke Statistics in Korea: Part I. Epidemiology and Risk Factors: A Report from the Korean Stroke Society and Clinical Research Center for Stroke [PDF]

, 2013
The aim of the Part I of Stroke Statistics in Korea is to summarize nationally representative data of the epidemiology and risk factors of stroke in a single document. Every year, approximately 105,000 people experience a new or recurrent stroke and more
허지회
core   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Antiplatelet Therapy May Be Insufficient to Prevent Stroke Recurrence Before Percutaneous Patent Foramen Ovale Closure [PDF]

Journal of Stroke, 2023
Hiroyuki Kawano, Yuko Honda, Takashi Johno, Hibiku Maruoka, Kaoru Nakanishi, Mikito Saito, Kensuke Ogata, Atsushi Yamamichi, Ayane Kawatake, Teruyuki Hirano   +9 more
doaj   +1 more source

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source