Results 131 to 140 of about 5,579,144 (303)

Integrating Time‐Adjusted Imaging Instability Into Functional Outcome Prediction After Intracerebral Hemorrhage: Development and Validation of the HAGIV Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Early risk stratification may support clinical decision‐making in spontaneous intracerebral hemorrhage (ICH). We aimed to develop and internally validate HAGIV, a score integrating frequency of imaging markers (FIM), a time‐adjusted non‐contrast computed tomography (CT) metric of hematoma expansion, with established predictors for 90‐
Lei Song, Ren Ke, Anqi Chen, Yufei Fu, Hang Zhou, Rujia Wang, Liwei Zou, Yongqiang Yu, Ming Yuan, Xiaoming Qiu, Mengzhou Xue   +10 more
wiley   +1 more source

A comparison of conscious sedation and local anesthesia for thrombectomy in acute ischemic stroke: a multicenter study

Frontiers in Neurology
IntroductionIschemic cerebrovascular disease (ICVD) is a serious health problem in which brain tissue suffers from hypoxic damage due to obstruction in cerebral vessels. Mechanical thrombectomy is a commonly used method in the treatment of these patients.
Aysenur Onalan, Erdem Gurkas, Cetin Kursad Akpinar, Özlem Aykaç, Turkan Acar, Bilgehan Acar, Zehra Uysal Kocabaş, Hasan Doğan, Ferhat Balgetir, Sule Kavak Genc, Ahmet Yabalak, Atilla Ozcan Ozdemir   +11 more
doaj   +1 more source

Advancing Stroke Clinical Trials Using Community Engagement and Implementation Science Approaches

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Stroke clinical trials are essential for advancing stroke care but can face challenges with recruitment, retention, clinical relevance, and translation into real‐world practice. We propose that integrating community engagement and implementation science approaches into stroke trials can help address these needs.
Lesli E. Skolarus, Devin L. Brown, Bernadette Boden‐Albala   +2 more
wiley   +1 more source

Computed Tomography Radiomic Signatures Associated With Neutrophil Extracellular Trap Enrichment and First‐Pass Outcome in Ischemic Stroke Thrombi

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Radiomic and transcriptomic analyses have independently identified features linked to mechanical thrombectomy (MT) outcomes. Here, we integrated paired radiomics/transcriptomics of stroke clots to identify neutrophil extracellular trap (NET ...
Briana A. Santo, Tatsat R. Patel, Seyyed M. Mousavi Janbeh Sarayi, Kerry E. Poppenberg, Sarah Balghonaim, Alexandria Scotti, TaJania D. Jenkins, Vinay Jaikumar, Elad I. Levy, Adnan H. Siddiqui, John Kolega, Vincent M. Tutino   +11 more
doaj   +1 more source

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source

Characteristics of acute occlusion of the intracranial vertebral artery and endovascular treatment

Scientific Reports
To investigate the characteristics of acute occlusion of the intracranial vertebral artery (IVA) and endovascular treatment. Patients with acute IVA occlusion treated with endovascular thrombectomy were prospectively enrolled, and the clinical, treatment
Yun-Peng Li, Zhi-Long Zhou, Yang Zhang, Li-Na Wang, Li-Heng Wu, Liang-Fu Zhu, Tian-Xiao Li, Bulang Gao   +7 more
doaj   +1 more source

Factors Associated With the Rising Trend in Self‐Reported Cognitive Disability Among U.S. Adults Aged 18–39 From 2013–2024

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Building on our prior Behavioral Risk Factor Surveillance System analysis identifying adults aged 18–39 as the primary driver of the national increase in self‐reported cognitive disability, we examined factors associated with this rise using 2013–2024 U.S. BRFSS data. Methods We analyzed U.S.
Adam de Havenon, Ka‐Ho Wong, Mirriam Mananah, Christopher D. Anderson, Ada Fenick, Amy Arnsten, Arman Fesharaki‐Zadeh, James C. McPartland, Mary L. Adams, Kevin N. Sheth   +9 more
wiley   +1 more source

Development and validation of the Life after Stroke questionnaire as a patient-reported outcome measure for stroke survivors living at home

Scientific Reports
Cerebrovascular disease is a leading cause of death and permanent neurological impairment worldwide. The goal of this study is to develop and validate a patient-reported outcome measure (PROM) that evaluates the daily lives of stroke survivors living at ...
Wolfgang Brunner, Christoph Zenzmaier, Nina Huber, Julian Granna, Kurt Mölgg, Benjamin Dejakum, Silvia Felicetti, Anel Karisik, Stefan Kiechl, Christian Boehme, Michael Knoflach   +10 more
doaj   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

Eligibility and Predictors for Acute Revascularization Procedures in a Stroke Center.

, 2016
Endovascular treatment (EVT) is a new standard of care for selected, large vessel occlusive strokes. We aimed to determine frequency of potentially eligible patients for intravenous thrombolysis (IVT) and EVT in comprehensive stroke centers. In addition,
Vanacker, P., Maghraoui, A., Lambrou, D., Eskandari, A., Mosimann, P.J., Michel, P.   +5 more
core   +1 more source