Results 101 to 110 of about 9,050,275 (263)

Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration [PDF]

, 2010
Ischemic stroke is the second leading cause of death worldwide. Only one moderately effective therapy exists, albeit with contraindications that exclude 90% of the patients.
Shah, Ajay M., Sven G. Meuth, de Angelis, MH, Henrike Grund, Schmidt, HHHW, Grund, Henrike, Schuhmann, M.K., Hrabě de Angelis, M., Sabine Meurer, Schrewe, A., Stoll, G., Peter Kraft, Martin Hrabé de Angelis, Barit, David, Barit, D., Schwarz, Tobias, de Angelis, Martin Hrabe, Stoll, Guido, Shah, AM, Klopstock, T., Weissmann, N, Schrewe, A, Mittal, M, Herrmann, A.M., Jones, Emma, Konstanze Barthel, Gailus-Durner, Valérie, Hrabé de Angelis, Martin, Kraft, Peter, Becker, L., Fuchs, H, Jandeleit-Dahm, Karin, Anja Schrewe, Harald H. H. W, Herrmann, AM, David Barit, Sven G Meuth, Meurer, S., Weissmann, Norbert, Schmidt, H.H., Michael K. Schuhmann, Kraft, P., Schuhmann, Michael K., Weissmann, N., Meuth, SG, Schwarz, T, Karin Jandeleit-Dahm, Barthel, Konstanze, Herrmann, Alexander M., Stoll, G, Meurer, Sabine, Schmidt, Harald H. H. W., Guido Stoll, Wingler, K., Christian Geis, Mittal, Manish, Lore Becker, Schrewe, Anja, Klopstock, Thomas, Fuchs, Helmut, Shah, A.M., Jandeleit-Dahm, K, Gailus-Durner, V, Barthel, K., Ajay M. Shah, Klopstock, T, Manish Mittal, Armitage, Melanie E., Meuth, S.G., Norbert Weissmann, Harald H. H. W. Schmidt, Kraft, P, Michael K Schuhmann, Hrabe ́ De Angelis, Grund, H, Meuth, Sven G., Jones, E., Thomas Klopstock, Geis, C, Schuhmann, MK, Tobias Schwarz, Grund, H., Kleinschnitz, Christoph, Melanie E Armitage, Barthel, K, Meurer, S, Kleinschnitz, C, Fuchs, H., Armitage, ME, Kleinschnitz, C., Kirstin Wingler, Valérie Gailus-Durner, Geis, Christian, Geis, C., Jones, E, Karin J, Gailus-Durner, V., Emma Jones, Becker, L, Jandeleit-Dahm, Karin A., Wingler, Kirstin, Helmut Fuchs, Mittal, M., Schwarz, T., Armitage, M.E., Er M. Herrmann, Jandeleit-Dahm, K., Harald H H W Schmidt, Becker, Lore, Ajay M Shah, Christoph Kleinschnitz, Alexander M. Herrmann, Wingler, K, Alexander M Herrmann, Melanie E. Armitage, Barit, D, Kraft Peter, Mittal Manish, Klopstock Thomas, Meurer Sabine, Schwarz Tobias, Jones Emma, Schuhmann Michael K., Barit David, Barthel Konstanze, Geis Christian, Schmidt Harald H. H. W., de Angelis Martin Hrabé, Fuchs Helmut, Kleinschnitz Christoph, Armitage Melanie E., Kleinschnitz, C. ; Grund, H. ; Wingler, K. ; Armitage, M.E. ; Jones, E. ; Mittal, M. ; Barit, D. ; Schwarz, T. ; Geis, C. ; Kraft, P. ; Barthel, K. ; Schuhmann, M.K. ; Herrmann, A.M. ; Meuth, S.G. ; Stoll, G. ; Meurer, S. ; Schrewe, A. ; Becker, L. ; Gailus-Durner, V. ; Fuchs, H. ; Klopstock, T. ; Hrabé de Angelis, M. ; Jandeleit-Dahm, K. ; Shah, A.M. ; Weissmann, N. ; Schmidt, H.H., Wingler Kirstin, Stoll Guido, Weissmann Norbert, Schrewe Anja, Jandeleit-Dahm Karin, Meuth Sven G., Shah Ajay M., Herrmann Alexander M., Grund Henrike, Gailus-Durner Valérie, Becker Lore   +142 more
core   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Can we improve the statistical analysis of stroke trials? Statistical re-analysis of functional outcomes in stroke trials [PDF]

, 2007
Background: Most large acute stroke trials have been neutral. Functional outcome is usually analysed using a yes or no answer, e.g. death or dependency vs. independence.
Optimising Analysis of Stroke Trials Collaboration, OAST, Bath, Philip M.W.   +1 more
core   +1 more source

Reliability of hemodynamic parameters measured by bioimpedance cardiography at different intensities during incremental exercise testing

Frontiers in Cardiovascular Medicine
BackgroundBioimpedance cardiography offers a non-invasive and time-efficient method to measure hemodynamic parameters. Previous studies only investigated its reliability under steady-state conditions and at maximum load but not at ventilatory thresholds (
Raphael Schoch, Jonathan Wagner, Max Niemeyer, Fabienne Bruggisser, Denis Infanger, Justin Carrard, Benedikt Gasser, Arno Schmidt-Trucksäss, Arno Schmidt-Trucksäss, Raphael Knaier   +9 more
doaj   +1 more source

Minimal Change in Cardiac Index With Increasing PEEP in Pediatric Acute Respiratory Distress Syndrome

Frontiers in Pediatrics, 2019
Objective: To determine if increasing positive end expiratory pressure (PEEP) leads to a change in cardiac index in children with Pediatric Acute Respiratory Distress Syndrome ranging from mild to severe.Design: Prospective interventional study.Setting ...
Manpreet K. Virk, Justin C. Hotz, Wendy Wong, Robinder G. Khemani, Christopher J. L. Newth, Patrick A. Ross   +5 more
doaj   +1 more source

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram, Guangwei Du, Sangam Kanekar, Nandakumar Nagaraja   +3 more
wiley   +1 more source

Ability of Passive Leg Raising Test in Predicting Positive Fluid Response in Paediatric Patients with Shock: A Prospective Observational Study

Journal of Clinical and Diagnostic Research
Introduction: Shock is an acute syndrome in which the circulatory system is unable to provide adequate oxygen and nutrients to meet the metabolic demands of vital organs.
Ritu Gupta, Mohd Kashif Ali, Yousuf Siddiqui   +2 more
doaj   +1 more source

Perioperative Goal-Directed Therapy Using Invasive Uncalibrated Pulse Contour Analysis

Frontiers in Medicine, 2018
“Perioperative goal-directed therapy” (PGDT) aims at an optimization of basic and advanced global hemodynamic variables to maintain adequate oxygen delivery to the end-organs.
Bernd Saugel, Daniel A. Reuter
doaj   +1 more source

Changes in Immune‐Inflammation Status and Prognosis in Pregnancy‐Related Cerebral Venous Thrombosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Distinguishing pathological changes from physiological adaptations in pregnancy‐related cerebral venous thrombosis (CVT) is clinically challenging. This study aimed to characterize coagulation, immune‐inflammation, and dehydration status in these patients and assess their prognostic value.
Xiaoming Zhang, Zilin Xu, Ran Duan, Chunxiao Lu, Da Zhou, Chen Zhou, Ran Meng, Xunming Ji   +7 more
wiley   +1 more source

Insular cortex hypoperfusion and acute phase blood glucose after stroke: a CT perfusion study [PDF]

, 2007
<p><b>Background and Purpose:</b> Insular cortex ischemia is proposed to mediate a sympathetic stimulus that leads to acute hyperglycemia after stroke.</p> <p><b>Methods:</b> We retrospectively analyzed ...
Muir, K.W., McCormick, M., Moreton, F.C.
core   +1 more source