Results 191 to 200 of about 779,727 (355)
Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis
Advanced Science, EarlyView.Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu +16 morewiley +1 more sourceLong‐Term Effects of Xenotransplantation of Human Enteric Glia in an Immunocompetent Rat Model of Acute Brain Injury
Advanced Science, EarlyView.Acute brain injuries are characterized by extensive tissue damage, resulting in debilitating deficits in patients. Despite considerable progress, cell‐based approaches have yet to identify an ideal candidate. This long‐term study explores the use of an untested cell source – human enteric glia – and a non‐invasive administration route – intranasal ...Nina Colitti, Edwige Rice, Franck Desmoulin, Maylis Combeau, Mélissa Parny, Lorenne Robert, Etienne Buscail, Barbara Bournet, Nathalie Vergnolle, Isabelle Raymond‐Letron, Isabelle Loubinoux, Carla Cirillo +11 morewiley +1 more sourceDeep learning-based white matter lesion volume on CT is associated with outcome after acute ischemic stroke
Henk van Voorst, Johanna Pitkänen, Laura van Poppel, Lucas de Vries, Mahsa Mojtahedi, Laura Martou, Bart J. Emmer, Yvo B.W.E.M. Roos, Robert van Oostenbrugge, Alida A. Postma, Henk A. Marquering, Charles B.L.M. Majoie, Sami Curtze, Susanna Melkas, Paul Bentley, Matthan W.A. Caan, Diederik W.J. Dippel, Charles B.L.M. Majoie, Charles B.L.M. Majoie, Aad van der Lugt, Adriaan van Es, Pieter‐Jan van Doormaal, René van den Berg, Ludo F.M. Beenen, Bart J. Emmer, Stefan D. Roosendaal, Wim H. van Zwam, Alida A. Postma, Lonneke S.F. Yo, Menno Krietemeijer, Geert J. Lycklama, Jasper M. Martens, Sebastiaan Hammer, Anton Meijer, Reinoud P.H. Bokkers, Anouk van der Hoorn, Ido R. van den Wijngaard, Albert J. Yoo, Dick Gerrits, Robert van Oostenbrugge, Bart J. Emmer, Jonathan M. Coutinho, Martine T.B. Truijman, Julie Staals, H. Bart van der Worp, Hieronymus D. Boogaarts, Ben Jansen, Sanne M. Zinkstok, Yvo B.W.E.M. Roos, Peter J. Koudstaal, Diederik W.J. Dippel, Jonathan M. Coutinho, Koos Keizer, Sanne Manschot, Jelis Boiten, Henk Kerkhoff, Ido R. van den Wijngaard, Hester F. Lingsma, Diederik W.J. Dippel, Vicky Chalos, Olvert A. Berkhemer, Aad van der Lugt, Charles B.L.M. Majoie, Adriaan Versteeg, Lennard Wolff, Matthijs van der Sluijs, Henk van Voorst, Manon L. Tolhuisen, Hugo Ten Cate, Moniek P.M. de Maat, Samantha Donse-Donkel, Heleen van Beusekom, Aladdin Taha, Aarazo Barakzie, Vicky Chalos, Rob van de Graaf, Wouter van der Steen, Aladdin Taha, Samantha Donse-Donkel, Lennard Wolff, Kilian M. Treurniet, Sophie Berg, Natalie E. LeCouffe, Manon Kappelhof, Rik Reinink, Manon L. Tolhuisen, Leon A. Rinkel, Josje Brouwer, Agnetha A.E. Bruggeman, Henk van Voorst, Robert‐Jan B. Goldhoorn, Wouter H. Hinsenveld, Anne Pirson, Susan Olthuis, Simone Uniken Venema, Sjan Teeselink, Lotte Sondag, Sabine L. Collette, Martin Sterrenberg, Naziha el Ghannouti +99 moreopenalex +2 more sourcesConstruction of a Multitissue Cell Atlas Reveals Cell‐Type‐Specific Regulation of Molecular and Complex Phenotypes in Pigs
Advanced Science, EarlyView.This research conducts an in‐depth investigation of cell‐type‐specific regulatory mechanisms underlying molecular and complex phenotypes through integrative analysis of multitissue single‐nucleus RNA sequencing, bulk RNA‐seq, and genome‐wide association study (GWAS) data in pigs.Lijuan Chen, Houcheng Li, Jinyan Teng, Zhen Wang, Xiaolu Qu, Zhe Chen, Xiaodian Cai, Haonan Zeng, Zhonghao Bai, Jinghui Li, Xiangchun Pan, Leyan Yan, Fei Wang, Lin Lin, Yonglun Luo, Goutam Sahana, Mogens Sandø Lund, Maria Ballester, Daniel Crespo‐Piazuelo, Peter Karlskov‐Mortensen, Merete Fredholm, Alex Clop, Marcel Amills, Crystal Loving, Christopher K. Tuggle, Ole Madsen, Jiaqi Li, Zhe Zhang, George E. Liu, Jicai Jiang, Lingzhao Fang, Guoqiang Yi +31 morewiley +1 more sourceEcologically‐Valid Emotion Signatures Enhance Mood Disorder Diagnostics
Advanced Science, EarlyView.This study identifies ecologically‐valid Divergent Emotional Functional Networks (DEFN), derived from dynamic functional connectivity during naturalistic movie watching. The DEFN reliably enhances diagnostic accuracy for mood disorders, including major depressive and bipolar disorders, demonstrating strong reproducibility across demographic factors and Shuyue Xu, Linling Li, Ting Luo, Gan Huang, Li Zhang, Benjamin Becker, Zhen Liang +6 morewiley +1 more sourceReevaluating risk assessment in connective tissue disease-associated pulmonary arterial hypertension: The prognostic superiority of stroke volume index. [PDF]
Rheumatol Immunol ResCai Q, Ye H, Zhang Y, Dai J, Shan L, Zhou Z, Li D, Liu T, Zhou Y, Yuan F, Sun X. +10 moreeuropepmc +1 more source