Results 321 to 330 of about 4,090,604 (368)

Senkyunolide I Improves Septicemia‐Induced Brain Dysfunction via Regulating Nrf2 and Astrocyte Activity.

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Senkyunolide I (Sen I) has a protective effect on the blood–brain barrier (BBB) in rats with sepsis‐associated encephalopathy (SAE). This study investigated whether Sen I regulates Nrf2 to ameliorate sepsis‐induced brain dysfunction (SIBD). Sixty rats were randomly assigned into Sham group, SAE group (Model group), SAE + Sen I group (72 mg/kg,
Haohao Cao, Tao Liu, Meixia Xu
wiley   +1 more source

Solanidine‐derived CYP2D6 phenotyping elucidates phenoconversion in multimedicated geriatric patients

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Phenoconversion, a genotype‐phenotype mismatch, challenges a successful implementation of personalized medicine. The aim of this study was to detect and determine phenoconversion using the solanidine metabolites 3,4‐seco‐solanidine‐3,4‐dioic acid (SSDA) and 4‐OH‐solanidine as diet‐derived cytochrome P450 2D6 (CYP2D6) biomarkers in a ...
Jens Andreas Sarömba, Julian Peter Müller, Jolanta Tupiec, Anjali Roeth, Berkan Kurt, Florian Kahles, Thea Laurentius, Cornelius Bollheimer, Julia C. Stingl, Katja S. Just   +9 more
wiley   +1 more source

The feasibility of pharmacokinetic‐based dosing of hydroxyurea for children with sickle cell anaemia in Uganda: Baseline results of the alternative dosing and prevention of transfusions trial

British Journal of Clinical Pharmacology, EarlyView.
Abstract Pharmacokinetic (PK)‐guided dosing of hydroxyurea for children with sickle cell anaemia (SCA) could optimize dosing and improve outcomes, but its feasibility has not been demonstrated in low‐resource settings where the majority of affected children live.
Alexandra Power‐Hays, Ruth Namazzi, Min Dong, Caroline Kazinga, Charles Kato, Sadat Aliwuya, Kathryn McElhinney, Andrea L. Conroy, Adam Lane, Chandy John, Alexander A. Vinks, Teresa Latham, Robert O. Opoka, Russell E. Ware   +13 more
wiley   +1 more source

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Stroke Volume Determination by Echocardiography

Chest, 2022
Basic critical care echocardiography emphasizes two-dimensional (2D) findings, such as ventricular function, inferior vena cava size, and pericardial assessment, while generally excluding quantitative findings and Doppler-based techniques. Although this approach offers advantages, including efficiency and expedited training, it complicates attempts to ...
Michael Sattin, Zain Burhani, Atul Jaidka, Scott J. Millington, Robert T. Arntfield   +4 more
openaire   +2 more sources

Abstract 1: The Very Core Limit Of Endovascular Therapy For Acute Stroke With A Large Ischemic Region

Stroke, 2023
Background and Purpose: To assess the actual malignant core volume in endovascular therapy (EVT) eligible patients with large ischemic regions from the RESCUE-Japan LIMIT database.
M. Inoue, T. Yoshimoto, K. Toyoda, N. Sakai, H. Yamagami, Y. Matsumaru, Y. Matsumoto, K. Kimura, R. Ishikura, K. Uchida, M. Beppu, Fumihiro Sakakibara, T. Morimoto, S. Yoshimura   +13 more
semanticscholar   +1 more source

Estimation of Stroke Volume and Stroke Volume Changes by Electrical Impedance Tomography

Anesthesia & Analgesia, 2018
BACKGROUND: Electrical impedance tomography (EIT) is a noninvasive imaging method that identifies changes in air and blood volume based on thoracic impedance changes. Recently, there has been growing interest in EIT to measure stroke volume (SV).
Andre Hovnanian, Eduardo L. V. Costa, Rogério Souza, Luciano Cesar Pontes Azevedo, Marcelo B. P. Amato, Fernando José da Silva Ramos   +5 more
openaire   +3 more sources

The Changes in Pulse Pressure Variation or Stroke Volume Variation After a “Tidal Volume Challenge” Reliably Predict Fluid Responsiveness During Low Tidal Volume Ventilation*

Critical Care Medicine, 2017
Objectives: Stroke volume variation and pulse pressure variation do not reliably predict fluid responsiveness during low tidal volume ventilation. We hypothesized that with transient increase in tidal volume from 6 to 8 mL/kg predicted body weight, that ...
S. Myatra, N. Prabu, J. Divatia, X. Monnet, A. Kulkarni, J. Teboul   +5 more
semanticscholar   +1 more source

Changes in Stroke Volume Induced by Lung Recruitment Maneuver Predict Fluid Responsiveness in Mechanically Ventilated Patients in the Operating Room

Anesthesiology, 2017
Background: Lung recruitment maneuver induces a decrease in stroke volume, which is more pronounced in hypovolemic patients. The authors hypothesized that the magnitude of stroke volume reduction through lung recruitment maneuver could predict preload ...
M. Biais, R. Lanchon, M. Sesay, Lisa Le Gall, Bruno Pereira, E. Futier, K. Nouette-Gaulain   +6 more
semanticscholar   +1 more source