Results 81 to 90 of about 2,243,492 (285)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

A Novel Hybrid Edge Detection Method for Polarimetric SAR Images

open access: yesIEEE Access, 2020
The edge detection plays an important role in post-processing of PolSAR images. It is still a great challenge for extracting all the edge features and suppress speckle noises, especially when weak/strong edges appear simultaneously outside and within ...
Junfei Shi, Haiyan Jin, Zhaolin Xiao
doaj   +1 more source

Kondo lattice on the edge of a two-dimensional topological insulator

open access: yes, 2012
We revisit the problem of a single quantum impurity on the edge of a two-dimensional time-reversal invariant topological insulator and show that the zero temperature phase diagram contains a large local moment region for antiferromagnetic Kondo coupling ...
A. M. Tsvelik   +7 more
core   +2 more sources

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

VNF Placement for Service Function Chains with Strong Low-Delay Restrictions in Edge Computing Networks

open access: yesApplied Sciences, 2020
The edge computing paradigm, allowing the location of network services close to end users, defines new network scenarios. One of them considers the existence of micro data centers, with reduced resources but located closer to service requesters, to ...
Pilar Manzanares-Lopez   +2 more
doaj   +1 more source

Topologically non-trivial Floquet band structure in a system undergoing photonic transitions in the ultra-strong coupling regime

open access: yes, 2015
We consider a system of dynamically-modulated photonic resonator lattice undergoing photonic transition, and show that in the ultra-strong coupling regime such a lattice can exhibit non-trivial topological properties, including topologically non-trivial ...
Fan, Shanhui, Yuan, Luqi
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Characterizations of Graphs Having Large Proper Connection Numbers

open access: yesDiscussiones Mathematicae Graph Theory, 2016
Let G be an edge-colored connected graph. A path P is a proper path in G if no two adjacent edges of P are colored the same. If P is a proper u − v path of length d(u, v), then P is a proper u − v geodesic. An edge coloring c is a proper-path coloring of
Lumduanhom Chira   +2 more
doaj   +1 more source

Dynamic defects in photonic Floquet topological insulators

open access: yes, 2017
Edge modes in topological insulators are known to be robust against defects. We investigate if this also holds true when the defect is not static, but varies in time. We study the influence of defects with time-dependent coupling on the robustness of the
Fleischhauer, Michael   +3 more
core   +1 more source

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