Results 111 to 120 of about 3,628,150 (288)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The shadowing chain lemma for singular Hamiltonian systems involving strong forces

Open Mathematics, 2012
Izydorek Marek, Janczewska Joanna
doaj   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Homoclinic orbits for a class of singular second order Hamiltonian systems in ℝ3

Open Mathematics, 2012
Janczewska Joanna, Maksymiuk Jakub
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Power assessment of lower limbs and strength asymmetry of soccer goalkeepers

Acta Universitatis Palackianae Olomucensis. Gymnica, 2013
BACKGROUND: Effective execution of vertical jump depends on the explosive power of lower limbs and their symmetrical integration mainly. Assessment of lower extremity bilateral asymmetries in soccer players is important for both injury prevention and ...
František Zahálka, Tomáš Malý, Lucia Malá, Tomáš Gryc, Pavel Hráský   +4 more
doaj  

Effect of Relative Isometric Strength on Countermovement Jump Performance in Professional and Semi-Professional Soccer Players

Biomechanics
As powerful actions commonly proceed goal scoring opportunities within soccer, enhancing powerful actions could be essential to optimize performance. There is a large body of evidence supporting the positive associations between maximal isometric mid ...
Nicholas Joel Ripley, Jack Fahey, Nabil Hassim, Paul Comfort   +3 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Validating Capacitive Pressure Sensors for Mobile Gait Assessment

Biomechanics
Background: This study was performed to validate the addition of capacitive-based pressure sensors to an existing smart sock developed by the research team.
John Carver Middleton, David Saucier, Samaneh Davarzani, Erin Parker, Tristen Sellers, James Chalmers, Reuben F. Burch, John E. Ball, Charles Edward Freeman, Brian Smith, Harish Chander   +10 more
doaj   +1 more source