Results 91 to 100 of about 7,423,432 (277)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Matching preclusion and strong matching preclusion of the bubble-sort star graphs

, 2020
Since a plurality of processors in a distributed computer system working in parallel, to ensure the fault tolerance and stability of the network is an important issue in distributed systems. As the topology of the distributed network can be modeled as a graph, the (strong) matching preclusion in graph theory can be used as a robustness measure for ...
Wang, Xin, Ma, Chaoqun, Guo, Jia
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Some Concepts of Interval Valued Pythagorean Fuzzy Graphs and Analysis of Socioeconomic Conditions of Communities

IEEE Access
The concepts of covering and matching in fuzzy graphs have played a significant role in addressing problems within uncertain and imprecise environments.
Waheed Ahmad Khan, Izhar Ahmed Shah, Trung Tuan Nguyen, Minh Hoan Pham, Hai van Pham   +4 more
doaj   +1 more source

Quadratic Matching Algorithm of Ancient Ceramic Fragments Based on Concavity-Convexity and Steering Angle [PDF]

Jisuanji gongcheng
Fragment splicing is the key work in ancient ceramic repair. To address the problems of the random shapes, large number, weak surface textures, and local defects of ancient ceramic fragments (which result in a low accuracy and long matching time of the ...
LIU Penghuan, ZHOU Qiang, WANG Ying, ZHU Jianfeng, LUO Hongjie, WANG Lu, WANG Tian
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

A Robust Multimodal Wide-Field Satellite Image Registration Algorithm Based on Weighted Random Partition Optimization

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Continuous advancements in sensor technology have expanded the dimensions and diversity of satellite imagery, yet intensified geometric processing challenges for multimodal remote sensing images (MRSIs).
Da He, Jiabei Zhang, Zhao Tan, Jiwei Deng, Guangshuai Wang, Yongxiang Yao, Yi Wan, Jiangping Chen, Yansheng Li, Yongjun Zhang   +9 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

NCI-MATCH Trial Draws Strong Interest [PDF]

Cancer Discovery, 2016
Abstract After 800 cancer patients enrolled during the first 3 months of the NCI-MATCH trial, organizers have extended a temporary halt in enrollment to gear up for the next phase. The basket study, which matches patients to approved or experimental drugs based on specific genetic mutations in their tumors, is expected to resume in April
openaire   +1 more source