Results 31 to 40 of about 133,073 (208)
New results on metric-locating-dominating sets of graphs [PDF]
, 2016 A dominating set $S$ of a graph is a metric-locating-dominating set if each vertex of the graph is uniquely distinguished by its distances from the elements of $S$, and the minimum cardinality of such a set is called the metric-location-domination number.
González, Antonio +2 more
core +3 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
On the strong partition dimension of graphs [PDF]
, 2013 We present a different way to obtain generators of metric spaces having the property that the ``position'' of every element of the space is uniquely determined by the distances from the elements of the generators.
Yero, Ismael Gonzalez
core
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Minimal doubly resolving sets and the strong metric dimension of Hamming graphs
Applicable Analysis and Discrete Mathematics, 2012 We consider the problem of determining the cardinality ?(H2,k) of minimal doubly resolving sets of Hamming graphs H2,k. We prove that for k ? 6 every minimal resolving set of H2,k is also a doubly resolving set, and, consequently, ?(H2,k) is equal to the metric dimension of H2,k, which is known from the literature.
Jozef Kratica +3 more
openaire +3 more sources
A Comparison between the Metric Dimension and Zero Forcing Number of Trees and Unicyclic Graphs
, 2017 The \emph{metric dimension} $\dim(G)$ of a graph $G$ is the minimum number of vertices such that every vertex of $G$ is uniquely determined by its vector of distances to the chosen vertices.
Eroh, Linda, Kang, Cong X., Yi, Eunjeong
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source