Results 111 to 120 of about 8,052,743 (293)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Advances in Nonlinear AnalysisThis paper investigates a blow-up criterion for strong solutions to the Dirichlet problem of a compressible isentropic two-phase flow model under the influence of a magnetic field, allowing initial vacuum states.
Zhu Limei, Wu Yongjun
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Strong Solution for a Nonlinear Non-Newtonian Shear Thickening Fluid
MathematicsThis paper consider a nonlinear shear thickening fluid in one dimensional bounded interval. The model illustrates that the movement of the compressible fluid is driven by non-Newtonian gravity, and represents a more realistic phenomenon.
Yukun Song, Lin Jin, Yang Chen
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Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Strong Solutions and Mild Solutions for Sturm-Liouville Differential Inclusions
Set-Valued and Variational AnalysisAbstractExistence results for a Cauchy problem driven by a semilinear differential Sturm-Liouville inclusion are achived by proving, in a preliminary way, an existence theorem for a suitable integral inclusion. In order to obtain this proposition we use a recent fixed point theorem that allows us to work with the weak topology and the De Blasi measure ...
Tiziana Cardinali, Giulia Duricchi
openaire +3 more sources
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Strong Solutions of the Neuronal Responses System
Journal of Kufa for Mathematics and ComputerWe explore a connected reaction-diffusion system involving neural responses within limited convex open domains . Utilizing the Classical Faedo-Galerkin technique and employing compactness arguments, we establish the existence, uniqueness, and ...
Raad Abd, Ghassan A. Al-Juaifri
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Strong solutions for some nonlinear partial functional differential equations with infinite delay
Electronic Journal of Differential Equations, 2008 In this work, we use the Kato approximation to prove the existence of strong solutions for partial functional differential equations with infinite delay.
Khalil Ezzinbi, Mohamed Alia
doaj