Results 21 to 30 of about 1,520 (239)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
, 1997 For an infinite cardinal α, we say that a subset B of a space X is Cα-compact in X if for every continuous function f : X → Rα, [B] is a compact subset of Rα. This concept slightly generalizes the notion of α-pseudocompactness introduced by J.F. Kennison:
García-Ferreira, S. +2 more
core +1 more source
Regular Ultrafilters and Finite Square Principles [PDF]
, 2007 We show that many singular cardinals λ above a strongly compact cardinal have regular ultrafilters D that violate the finite square principle fin λ,D introduced in [3]. For such ultrafilters D and cardinals
Väänänen, J. +5 more
core +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
Strongly compact cardinals and SCH
, 2020 The thesis is devoted to the cardinal arithmetic. The first step is to formulate the Singular Cardinals Hypothesis (SCH) which simplifies the cardinal exponentiation of sin- gular cardinal numbers.
Narusevych, Mykyta
core
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Effect of terahertz irradiation on DNA damage repair in living cells
FEBS Open Bio, EarlyView.We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno +3 more
wiley +1 more source
, 1982 Let X X be a compact Hausdorff space and κ \kappa its Souslin number. 2 ^{2} We prove that if α \alpha is a cardinal such that either α
S. Argyros, A. Tsarpalias
core +1 more source
Accessible images revisited [PDF]
, 2017 We extend and improve the result of Makkai and Paré (1989) that the powerful image of any accessible functor F is accessible, assuming there exists a sufficiently large strongly compact cardinal.
Rosicky, Jiri +3 more
core +1 more source