Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang +10 more
wiley +1 more source
The study of strongly correlated electron systems remains a fundamental challenge in condensed matter physics, particularly in two-dimensional (2D) systems hosting various exotic phases of matter including quantum spin liquids, unconventional ...
Hui-Ke Jin +3 more
doaj +1 more source
Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley +1 more source
Density and temperature of energetic electrons in the Earth's magnetotail derived from high-latitude GPS observations during the declining phase of the solar cycle [PDF]
Single relativistic-Maxwellian fits are made to high-latitude GPS-satellite observations of energetic electrons for the period January 2006-November 2010; a constellation of 12 GPS space vehicles provides the observations. The derived fit parameters (for
Denton, Michael +3 more
core +4 more sources
Methods of Modeling of Strongly Correlated Electron Systems
The discovery of high-Tc superconductivity in cuprates in 1986 moved strongly correlated systems from exotic worlds interesting only for pure theorists to the focus of solid-state research. In recent decades, the majority of hot topics in condensed matter physics (high-Tc superconductivity, colossal magnetoresistance, multiferroicity, ferromagnetism in
openaire +3 more sources
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source
Gauge fixing for strongly correlated electrons coupled to quantum light
International audienceWe discuss the problem of gauge fixing for strongly correlated electrons coupled to quantum light, described by projected low-energy models such as those obtained within tight-binding methods.
Schiró, Marco, Dmytruk, Olesia
core +2 more sources
Theory of superconductivity in strongly correlated electron systems [PDF]
In the correlated electron system with the pseudogap, full-gapped domains and Fermi-arced domains coexist. These domains are created by the quantum-fluctuated antiferromagnetic correlation that generates the short-ranged attractive potential to produce the Fermi arcs and the superconductivity.
openaire +2 more sources
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
Integrable lattice models for strongly correlated electrons
THESIS 10279This thesis is dedicated to the study of a new family of integrable lattice models for strongly correlated electrons, namely the Hubbard- Shastry models. The techniques of exactly solvable models, and in particular those of integrable systems,
Quinn, Eoin
core

