Results 161 to 170 of about 870,024 (320)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

An extension of RPA theory to strongly-interacting systems [PDF]

, 1982
J. M. C. Chen, J. W. Clark, D. G. Sandier   +2 more
openalex   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Exchange and correlation effects in the strongly interacting He-Ps system [PDF]

, 2013
A. Zubiaga, Filip Tuomisto, M. J. Puska
openalex   +1 more source

Revealing the Nature of a Lyα Halo in a Strongly Lensed Interacting System at z = 2.92 [PDF]

, 2022
Manuel Solimano, Jorge González-López, Manuel Aravena, Evelyn J. Johnston, C. Moya-Sierralta, L. Felipe Barrientos, Matthew Bayliss, Michael D. Gladders, L. Infante, C. Ledoux, Sebastián López, Suraj Poudel, Jane R. Rigby, Keren Sharon, Nicolás Tejos   +14 more
openalex   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Large-scale analogue quantum simulation using atom dot arrays. [PDF]

Nature
Donnelly MB, Chung Y, Garreis R, Plugge S, Pye D, Kiczynski M, Támara-Isaza J, Munia MM, Sutherland S, Voisin B, Kranz L, Hsueh YL, Huq AMS, Myers CR, Rahman R, Keizer JG, Gorman SK, Simmons MY.   +17 more
europepmc   +1 more source

EPIC 220204960: A Quadruple Star System Containing Two Strongly Interacting Eclipsing Binaries [PDF]

, 2017
S. Rappaport, Andrew Vanderburg, T. Borkovits, B. Kalomeni, J. P. Halpern, Henry Ngo, Gregory N. Mace, Benjamin J. Fulton, Andrew W. Howard, Howard Isaacson, Erik A. Petigura, Dimitri Mawet, Martti H. Kristiansen, Thomas L. Jacobs, Daryll M. LaCourse, Allyson Bieryla, E. Forgács‐Dajka, L. A. Nelson   +17 more
openalex   +1 more source