Results 151 to 160 of about 965,004 (336)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Structural model of perfectionism, psychological well-being and marital adjustment

open access: yesفصلنامه روان‌شناسی کاربردی, 2018
Aim: The aim of the study was to determine structural model of perfectionism, psychological well-being, and marital adjustment. Method: Method was descriptive correlational and the statistical population included all residents of Karaj City (N=1614626 ...
راضیه نظری   +1 more
doaj  

Structural adjustment [PDF]

open access: yesAustralian Academic & Research Libraries, 1989
openaire   +1 more source

Managing Change: Australian structural adjustment lessons for water [PDF]

open access: yes
The purpose of this report is to search Australia's extensive experience in running and reviewing structural adjustment programs for insights of relevance to water reform.Water;Australia;Water reform;structural adjustment;rural;agricultural;policy.
Jim McColl, Michael Young, 2005.
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

STRUCTURAL ADJUSTMENT PROGRAMS AND PEANUT MARKET PERFORMANCE IN SENEGAL [PDF]

open access: yes
The impacts of Structural Adjustment Programs (SAPs) on social welfare are investigated using data from the Senegalese peanut sector. The findings suggest that SAP policies resulted in dramatic decreases in peanut production, undermining the ...
Hathie, Ibrahima, Lopez, Rigoberto A.
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

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