Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Theoretical study on structural and mechanical properties of Si-containing ternary transition metal nitrides M0.5Si0.5N (M = Ti, Zr, Hf). [PDF]
Chen L, Xie Q, Jia Y, Yao Y.
europepmc +1 more source
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu +11 more
wiley +1 more source
Sustainable PLA Composites Filled with Poaceae Fibers: Thermal, Structural, and Mechanical Properties. [PDF]
Kubiak N +9 more
europepmc +1 more source
The influence of estrogen deficiency on the structural and mechanical properties of rat cortical bone. [PDF]
Shipov A +7 more
europepmc +1 more source
ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu +5 more
wiley +1 more source
The Effect of Graphene Oxide Deposition, Shot Peening, and Hybrid Graphening on the Structural and Mechanical Properties of 30HGSA Steel. [PDF]
Stabryn S +10 more
europepmc +1 more source
Structural and Mechanical Properties of a-BCN Films Prepared by an Arc-Sputtering Hybrid Process. [PDF]
Hirata Y +7 more
europepmc +1 more source
ABSTRACT Objective People with epilepsy (PWE) may experience cognitive deficits but fail to undergo formal evaluation. This study compares cognitive status between PWE and healthy controls in the West African Republic of Guinea. Methods A cross‐sectional, case–control study was conducted in sequential recruitment phases (July 2024–July 2025) at Ignace ...
Maya L. Mastick +14 more
wiley +1 more source
Structural Evolution, Mechanical Properties, and Thermal Stability of Multi-Principal TiZrHf(Ta, Y, Cr) Alloy Films. [PDF]
Chen YI, Ou TY, Chang LC, Liao YZ.
europepmc +1 more source

