Results 91 to 100 of about 184,920 (263)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Structural Behaviour of Strengthened Composite Materials. Experimental Studies

Bulletin of the Polytechnic Institute of Jassy: Constructions, Architechture Section, 2007
Masonry represents one of the earliest structural materials used by mankind. A lot of the ancient building structures were made using masonry. A large number of these buildings have been stated historical monuments.
Vlad Munteanu, N. Ţăranu, M. Budescu, George Ţăranu   +3 more
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structural Behaviour and Design of Geopolymer Concrete Members

Civil Engineering Dimension, 2015
The worldwide production of concrete is on the increase in order to meet the increasing rate of construction. Since cement production contributes to the greenhouse gas emission, it is vital to develop alternative low-emission binders to reduce the ...
Sarker P.K.
doaj  

Structural behaviour of steel-timber composite elements: an overview

Low-Carbon Materials and Green Construction
This paper provides a comprehensive study on the structural behaviour of steel-timber composite elements through reviewing their composite assembly effect, capacity improvements, fire resistance, durability, maintenance, design considerations and ...
Mohamed Eldeib, Xing Ma, Yan Zhuge, Raufdeen Rameezdeen, Reza Hassanli, Mark Ellis, El-Sayed Abd-Elaal   +6 more
doaj   +1 more source

A Novel Modelling Methodology Which Predicts the Structural Behaviour of Vertebral Bodies under Axial Impact Loading: A Finite Element and DIC Study. [PDF]

Materials (Basel), 2020
Agostinho Hernandez B, Gill HS, Gheduzzi S.   +2 more
europepmc   +1 more source