Results 141 to 150 of about 23,423,883 (325)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Structural change in feedlot cattle death loss rates. [PDF]
Front Vet Sci, 2023 Buda M, Raper KC, Riley JM, Peel DS.
europepmc +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Deutschmark appreciation and structural change: An overview of economic structural reports [PDF]
Changes in exchange rates have become a prominent issue in Germany and Japan - due to the enormous appreciation of the Deutschmark and the Yen. Conventional wisdom suggests that economic activity will be negatively affected if a currency is going through
Schmidt, Klaus-Dieter
core
Is there structural change on MRI in gluteal tendinopathy after treatment? Single outcome measure extension of an RCT. [PDF]
BMC Med Imaging, 2023 Carney G, Fitzpatrick J.
europepmc +1 more source
Integration into Global Value Chains: Evidence from Mexico, 1995–2020
EconomiesThis paper examines Mexico’s integration into Global Value Chains (GVCs) and its implications for structural change over the period 1995–2020. Using a multiregional input–output framework, the analysis decomposes gross exports into domestic and foreign ...
Luisa Rivera-Basques +1 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Structural Change, Growth and Bazaar Effects in the Single EU Market [PDF]
This paper analyzes the link between structural change, growth and bazaar effects in the context of open economies. At first we consider the theoretical basis of structural change and discuss the interdependencies between trade, foreign direct investment
Dora Borbély, Paul J.J. Welfens
core
Habit formation viewed as structural change in the behavioral network. [PDF]
Commun Biol, 2023 Yamada K, Toda K.
europepmc +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source