Results 11 to 20 of about 71,369 (173)

The Fractal Dimension of SAT Formulas [PDF]

, 2013
Modern SAT solvers have experienced a remarkable progress on solving industrial instances. Most of the techniques have been developed after an intensive experimental testing process.
Ansótegui, C., Bonet, M. L., Giráldez-Cru, J., Levy, J.   +3 more
core   +3 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Convex Graph Invariant Relaxations For Graph Edit Distance [PDF]

, 2019
The edit distance between two graphs is a widely used measure of similarity that evaluates the smallest number of vertex and edge deletions/insertions required to transform one graph to another.
Candogan, Utkan Onur, Chandrasekaran, Venkat   +1 more
core   +1 more source

Inference using noisy degrees: Differentially private $\beta$-model and synthetic graphs

, 2016
The $\beta$-model of random graphs is an exponential family model with the degree sequence as a sufficient statistic. In this paper, we contribute three key results.
Karwa, Vishesh, Slavković, Aleksandra
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Henneberg constructions and covers of cone-Laman graphs [PDF]

, 2012
We give Henneberg-type constructions for three families of sparse colored graphs arising in the rigidity theory of periodic and other forced symmetric frameworks.
Theran, Louis
core  

Graphical Markov models, unifying results and their interpretation

, 2015
Graphical Markov models combine conditional independence constraints with graphical representations of stepwise data generating processes.The models started to be formulated about 40 years ago and vigorous development is ongoing.
Allman, Andersen, Anderson, Anderson, Andersson, Andersson, Barndorff-Nielsen, Birch, Bollen, Castelo, Castelo, Chaudhuri, Cochran, Cox, Cox, Cox, Cox, Cox, Darroch, Dawid, Dawid, Dempster, Dempster, Drton, Edwards, Edwards, Eichler, Evans, Fisher, Foygel, Fried, Frydenberg, Geiger, Gibbs, Glonek, Grcar, Green, Haberman, Højsgaard, Jiang, Jöreskog, Kauermann, Khare, Koster, Lauritzen, Lauritzen, Lauritzen, Letac, Lněnička, Loh, Lupparelli, Ma, Mabry, Marchetti, Marchetti, Markov, McCullagh, McCullagh, Nemeth, Neumann, Oliver, Ostrowski, Ostrowski, Pearl, Pearl, Pearl, Pearl, Reingold, Richardson, Robins, Roverato, Sadeghi, Sadeghi, Sadeghi, San Martin, Schur, Shpitser, Simpson, Speed, Speed, Spirtes, Stanghellini, Strotz, Studený, Sundberg, Tarjan, Tikhonov, Tukey, Uhler, Wainer, Wainwright, Weisberg, Wermuth, Wermuth, Wermuth, Wermuth, Wermuth, Wermuth, Wermuth, Wermuth, Wermuth, Wermuth, Wermuth, Wermuth, Wermuth, Wermuth, Wermuth, Wermuth, Wermuth, Wermuth, Wermuth, Whittaker, Wiedenbeck, Won, Wright, Wright, Zellner, Zwiernik   +117 more
core   +1 more source