Results 11 to 20 of about 166,148,780 (209)

Large-girth roots of graphs [PDF]

open access: yes, 2010
We study the problem of recognizing graph powers and computing roots of graphs. Our focus is on classes of graphs with no short cycles. We provide a polynomial time recognition algorithm for r-th powers of graphs of girth at least 2r vertical bar 3, thus
Adamaszek, Michal   +4 more
core   +1 more source

Testing first-order properties for subclasses of sparse graphs [PDF]

open access: yes, 2013
We present a linear-time algorithm for deciding first-order (FO) properties in classes of graphs with bounded expansion, a notion recently introduced by Nešetřil and Ossona de Mendez.
Thomas, Robin   +2 more
core   +1 more source

Polynomial-Time Derivation of Optimal $k$-Tree Topology from Markov Networks

open access: yesJournal of Graph Algorithms and Applications
Characterization of joint probability distribution for large networks of random variables remains a challenging task in data science. Probabilistic graph approximation with simple topologies has practically been resorted to; typically the tree topology ...
Fereshteh R. Dastjerdi, Liming Cai
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Families unlocking futures: Solutions to the crisis in juvenile justice [PDF]

open access: yes, 2012
“Families Unlocking Futures: Solutions to the Crisis in Juvenile Justice” introduces the informed and heartfelt perspective of families, the parents, and other relatives who are uniquely affected by the systems that can determine the future of their ...
Justice for Families
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

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