Results 81 to 90 of about 1,439,788 (292)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Sensitive Stretchable and Pressable Mechanochromic Photonic Crystals for Dynamic Displays and Visual Sensing

Advanced Sensor Research, 2023
Mechanochromic photonic crystals (MPCs) have shown wide applications in visual sensing, displays, anti‐counterfeiting, etc. However, most reported MPCs can only sense stretching or pressure and exhibit poor sensitivity, which greatly limits their ...
Boru Wei, Yang Hu, Dongpeng Yang, Shaoming Huang   +3 more
doaj   +1 more source

Structural Parameterizations for Equitable Coloring [PDF]

, 2020
An $n$-vertex graph is equitably $k$-colorable if there is a proper coloring of its vertices such that each color is used either $\left\lfloor n/k \right\rfloor$ or $\left\lceil n/k \right\rceil$ times. While classic Vertex Coloring is fixed parameter tractable under well established parameters such as pathwidth and feedback vertex set, Equitable ...
Guilherme de C. M. Gomes, Matheus R. Guedes, Vinícius Fernandes dos Santos   +2 more
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Influence of Ca₃(PO₄)₂ on the Surface Morphology and Properties of a CaO-Al₂O₃-SiO₂-Fe₂O₃-Based High Temperature Phase Reconstructed Complex

Molecules
In this study, a glaze slurry was prepared with different contents of tricalcium phosphate. It was then applied to a fly ash microcrystalline ceramic billet and sintered at 1180 °C for 30 min to prepare the complex.
Huanyin Yang, Hongli Guo, Hongjuan Sun, Tongjiang Peng   +3 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Structural color: an emerging nanophotonic strategy for multicolor and functionalized applications

Opto-Electronic Science
Color as an indispensable element in our life brings vitality to us and enriches our lifestyles through decorations, indicators, and information carriers.
Wenhao Wang, Long Wang, Qianqian Fu, Wang Zhang, Liuying Wang, Gu Liu, Youju Huang, Jie Huang, Haoyuan Zhang, Fuqiang Guo, Xiaohu Wu   +10 more
doaj   +1 more source

More Color More Pride: Addressing Structural Barriers to Interracial LGBTQ Loving [PDF]

, 2019
Through an examination of State-supported racial structures, this Essay illustrates that even after the legalization of interracial and same-sex marriages, the State’s control over housing, education, and employment prospects impedes the formation of ...
Prasad, Praatika
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source