Results 91 to 100 of about 222,541 (341)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Functional and structural connectivity of the amygdala underpins locus of control in mild cognitive impairment

open access: yesNeuroImage: Clinical, 2018
Locus of control (LOC) is an important personality trait. LOC over cognitive competency reflects an individual's perceived control of desired cognitive outcomes, which is critical for maintaining successful cognitive aging.
Ping Ren   +4 more
doaj   +1 more source

Studi Kinerja Pejabat Struktural Eselon III [PDF]

open access: yes, 2015
The results showed that 1) DiklatPim Tk. III has positive and significant impact on the performance of structural echelon III 2) top leadership behaviors has positive and significant impact on the performance of structural echelon officials III 3) work ...
Kusmana, E. (Engkus)
core  

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Maximizing Competency Education and Blended Learning: Insights from Experts [PDF]

open access: yes, 2015
In May 2014, CompetencyWorks brought together twenty-three technical assistance providers to examine their catalytic role in implementing next generation learning models, share each other's knowledge and expertise about blended learning and competency ...
Chris Sturgis, Susan Patrick
core  

Designing a competency based program to facilitate the progression of experienced engineering technologists to professional engineer status [PDF]

open access: yes, 2006
This paper describes the pedagogical principles that underpin the design of the Master of Engineering Practice, a distance education program offered by the University of Southern Queensland.
Dowling, David
core   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

HOW TO INCREASE EMPLOYEE’S DISCIPLINARY IN FACULTY MEDICINE OF DIPONEGORO UNIVERSITY [PDF]

open access: yes, 2012
Human Capital plays an important role in organization. It is the heart of the organization strategy. Many factors embeded in it. Public Service employees as government human capital instead of the contract employees.
SETYOWATI, RETNO
core   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

open access: yesAging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Adopting communicative language teaching (CLT) approach to enhance oral competencies among students: Teachers’ attitudes and beliefs [PDF]

open access: yes, 2007
The idea of communicative competence is one of the most influential theoretical developments in language education as it helps redefine the objectives of second language (L2) instruction.
Abdul Latif, Suzana   +3 more
core  

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