Results 201 to 210 of about 473,834 (321)

Opportunities in Middle Childhood: Multiple System Involvement During Middle Childhood and Early Adolescence in Northern Territory, Australia

Australian Journal of Social Issues, EarlyView.
ABSTRACT Middle childhood offers a crucial window to identify and support children at risk of adverse outcomes in adolescence. This retrospective cohort study examined how data from multiple systems could identify children with the greatest need for support during middle childhood and early adolescence. Using individual level linked records from health,
Vincent Yaofeng He, Jenny Williams, Steven Roche, Tamika Williams, Steven Guthridge   +4 more
wiley   +1 more source

Engineering Bodipy‐Based Metal–Organic Frameworks for Efficient Full‐Spectrum Photocatalysis in Amide Synthesis

Angewandte Chemie, EarlyView.
Three highly stable bodipy‐based metal–organic frameworks (BMOFs) were synthesized by treating dicarboxyl‐functionalized bodipy ligands with Zr‐oxo clusters. Featuring the distinct bodipy scaffold in the framework, these BMOFs displayed high reactivity in heterogenous photocatalytic C─H bond activation of N,N‐dimethylanilines to access amides under ...
Binhui Liu, Xu Chen, Yuhao Yang, Mohammad Reza Alizadeh Kiapi, Dhruv Menon, Qianyi Zhao, Guozan Yuan, Luke L. Keenan, David Fairen‐Jimenez, Qingchun Xia   +9 more
wiley   +2 more sources

Alzheimer's Association clinical practice guideline for the Diagnostic Evaluation, Testing, Counseling, and Disclosure of Suspected Alzheimer's Disease and Related Disorders (DETeCD‐ADRD): Executive summary of recommendations for primary care

Alzheimer's &Dementia, EarlyView.
Abstract US clinical practice guidelines for the diagnostic evaluation of cognitive impairment due to Alzheimer's disease (AD) or AD and related dementias (ADRD) are decades old and aimed at specialists. This evidence‐based guideline was developed to empower all—including primary care—clinicians to implement a structured approach for evaluating a ...
Alireza Atri, Bradford C. Dickerson, Carolyn Clevenger, Jason Karlawish, David Knopman, Pei‐Jung Lin, Mary Norman, Chiadi Onyike, Mary Sano, Susan Scanland, Maria Carrillo   +10 more
wiley   +1 more source

Streamlining SuFEx Inhibitor Development: A Unified Approach Using Photolabile and Orthogonal Sulfinate Protecting Groups

Angewandte Chemie, EarlyView.
This Study outlines the discovery and selection of sulfinate protecting groups (SPGs) based on their overall stability, ease of synthesis, and simple deprotection conditions, including two novel, photolabile SPGs that can be directly converted to the sulfonyl fluoride (SFs) using light and selectfluor.
Twinkle I. Patel, Makayla L. Williams, Yumeng Chi, Ramkrishna Laha, Matthew J. Moschitto   +4 more
wiley   +2 more sources

Elevated α‐Synuclein Aggregate Levels in the Urine of Patients with Isolated REM Sleep Behavior Disorder and Parkinson's Disease

Annals of Neurology, EarlyView.
Parkinson's disease (PD) is a neurodegenerative disorder characterized by α‐synuclein aggregation in neurons. Recent advances suggest α‐synuclein aggregates could serve as a biomarker for PD and related synucleinopathies. This study used surface‐based fluorescence intensity distribution analysis (sFIDA) to measure α‐synuclein aggregates in urine ...
Laura Müller, Pelin Özdüzenciler, Charlotte Schedlich‐Teufer, Aline Seger, Hannah Jergas, Gereon R. Fink, Dieter Willbold, Michael Sommerauer, Michael T. Barbe, Gültekin Tamgüney   +9 more
wiley   +1 more source

Enhancing Cold Adaptation of Bidomain Amylases by High‐Throughput Computational Engineering

Angewandte Chemie, EarlyView.
This work uncovers molecular determinants of cold adaptation in bidomain amylases by combining MD simulations and biochemical assays, revealing that increased domain separation drives enhanced activity at low temperatures. Guided by this principle, high‐throughput in silico linker screening of mesophilic psA was performed, yielding variant psA121 with ...
Ning Ding, Yaoyukun Jiang, Robbie Ge, Qianzhen Shao, Wook Shin, Xinchun Ran, Zhongyue J. Yang   +6 more
wiley   +2 more sources

Non‐Precious Metal Catalysts with Gradient Oxidative Dual Sites Boost Bimolecular Activation for Catalytic Oxidation Reactions

Angewandte Chemie, EarlyView.
Engineering highly active dual sites enhances catalytic oxidation reactions by optimizing bimolecular activation. By immobilizing Cu2+ on NO3⁻‐grafted TiO2 and applying thermal treatment, Ti‐doped CuO is successfully synthesized on a TiO2 support. This catalyst, featuring gradient oxidative Cu─O─Ti/Cu─O─Cu dual sites, shows strong potential for low ...
Yufei Wang, Tianwei Lan, Lupeng Han, Evangelina Pensa, Yongjie Shen, Xingchi Li, Zixiang Xu, Xin Chen, Mengxue Wang, Xiaoya Xue, Yanqing Li, Ming Xie, Emiliano Cortés, Dengsong Zhang   +13 more
wiley   +2 more sources

Asymmetric Aziridination of Allylic Carbamates Using Ion‐Paired Rhodium Complexes and Extrapolation to C─H Amination of Phenethyl Carbamates

Angewandte Chemie, EarlyView.
Aziridination of alkenes is an important route to chiral nitrogen‐containing building blocks. We report that carbamate‐functionalized allylic alcohols undergo highly enantioselective aziridination using achiral dimeric Rh complexes ion‐paired with cinchona alkaloid‐derived chiral cations.
Arthur R. Lit, Shotaro Takano, Christian Zachau, Ioana Băltărețu, Robert J. Phipps   +4 more
wiley   +2 more sources