Results 41 to 50 of about 4,015,508 (257)

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Altered thalamocortical structural connectivity in persons with schizophrenia and healthy siblings

NeuroImage: Clinical, 2020
Schizophrenia has long been framed as a disorder of altered brain connectivity, with dysfunction in thalamocortical circuity potentially playing a key role in the development of the illness phenotype, including psychotic symptomatology and cognitive ...
Beier Yao, Sebastiaan F.W. Neggers, René S. Kahn, Katharine N. Thakkar   +3 more
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Genetic analysis of structural brain connectivity using DICCCOL models of diffusion MRI in 522 twins [PDF]

, 2015
Genetic and environmental factors affect white matter connectivity in the normal brain, and they also influence diseases in which brain connectivity is altered.
McMahon, Katie L., Madelaine Daianu, Neda Jahanshad, Nicholas G. Martin, Katie L. McMahon, Zhu, Dajiang, Faskowitz, Joshua, De Zubicaray, Greig I., Jahanshad, Neda, Liang Zhan, Wright, Margaret J., Daianu, Madelaine, Dajiang Zhu, Joshua Faskowitz, Zhan, Liang, Martin, Nicholas G., Greig I. de Zubicaray, Thompson, Paul M., Margaret J. Wright, Paul M. Thompson   +19 more
core   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Structural connectivity preprocessing.

, 2016
The correlation between modeled and empirical functional connectivity for different preprocessing steps of structural connectivity. In the reference procedure, the number of tracked fibers between two regions was normalized by the product of the region ...
Peter König (62403), Christian Gerloff (66582), Claus Hilgetag (3140412), Marlene Bönstrup (3140415), Bastian Cheng (758880), Götz Thomalla (336027), Arnaud Messé (419295), Holger Finger (3140418)   +7 more
core   +1 more source

Tree representations of brain structural connectivity via persistent homology

Frontiers in Neuroscience, 2023
The brain structural connectome is generated by a collection of white matter fiber bundles constructed from diffusion weighted MRI (dMRI), acting as highways for neural activity.
Didong Li, Phuc Nguyen, Zhengwu Zhang, David Dunson   +3 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Prediction of Early Adolescent Functional Connectivity Development based on Preadolescent Structural Connectivity

, 2021
We will build a model that predicts adolescent functional connectivity based on preadolescent brain connectivity, genetic, and environmental features. In particular, we hypothesize that preadolescent structural connectivity predicts changes in functional
Sin Kim, Jaeseung Jeong
core   +1 more source

Predicting human resting-state functional connectivity from structural connectivity

, 2009
In the cerebral cortex, the activity levels of neuronal populations are continuously fluctuating. When neuronal activity, as measured using functional MRI (fMRI), is temporally coherent across 2 populations, those populations are said to be functionally ...
Sporns, O., Thiran, J. P., Honey, C. J., Gigandet, X., Meuli, R., Hagmann, P., Cammoun, L.   +6 more
core   +2 more sources