Results 111 to 120 of about 4,792,487 (297)

Structural diversity and evolutionary constraints of oxidative phosphorylation

Cell Genomics
Summary: The oxidative phosphorylation (OxPhos) system is central to metabolism. The more than 90 structural subunits are encoded by different chromosome categories (autosomal, X, and mtDNA).
José Luis Cabrera-Alarcón, Marina Rosa-Moreno, Lucía Sánchez-García, Pablo Hernansanz-Agustín, Maria Concepción Jiménez-Gómez, Fernando Martínez, Fátima Sánchez-Cabo, José Antonio Enríquez   +7 more
doaj   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Advancing Stroke Clinical Trials Using Community Engagement and Implementation Science Approaches

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Stroke clinical trials are essential for advancing stroke care but can face challenges with recruitment, retention, clinical relevance, and translation into real‐world practice. We propose that integrating community engagement and implementation science approaches into stroke trials can help address these needs.
Lesli E. Skolarus, Devin L. Brown, Bernadette Boden‐Albala   +2 more
wiley   +1 more source

Constraints and spandrels of interareal connectomes

Nature Communications, 2016
Whole-brain networks of long-range neuronal pathways are characterized by interdependencies between structural features. Here the author shows that module hierarchy and rich club features in these networks are structural byproducts (spandrels) of module ...
Mikail Rubinov
doaj   +1 more source

Minimum Hours Constraints, Job Requirements and Retirement [PDF]

A structural retirement model estimated with data from the Health and Retirement Study is used to simulate the effects of policies firms might adopt to improve employment conditions for older workers and thereby encourage delayed retirement.
Alan L. Gustman, Thomas L. Steinmeier
core  

Structural constraints on building decarbonization in electricity-dominant cities

Nexus
Electricity-dominant, high-density cities are often considered advantaged for decarbonization due to highly electrified building systems, yet many remain far from net zero.
Qiqi Huang, Shihong Zhang, Liutao Chen, Xinyu Wang, Zhe Wang, Chu Zhang   +5 more
doaj   +1 more source

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin, Tianyuan Yang, Minglei Liu, Haiyang Luo, Jing Yuan, Ke Zhang, Xinsheng Han, Jing Yang, Yuming Xu   +8 more
wiley   +1 more source

Structural studies of human cell surface receptors: On low-density lipoprotein receptor-related protein 1 and epidermal growth factor receptors 2 and 3 [PDF]

, 2017
The elucidation of proteins’ structure and function is of great importance for the understanding of disease triggering mechanisms and for the development of new drugs. In this thesis, different biophysical and biochemical techniques were employed to gain
Sub Crystal and Structural Chemistry, Crystal and Structural Chemistry, De Nardis, C.   +2 more
core  

Research on a 3D Quantification Method for Spillway Blockage Based on Structural Constraints and Dense 3D Reconstruction

工程科学与技术
Objective Spillway blockage in small reservoirs is difficult to inspect and quantify in a timely and reliable manner, particularly where maintenance conditions are limited and on-site investigation is not easily organized. Existing image-based inspection
DOU Yanzhe, ZHANG Jixun, REN Xuhua, ZHANG Yuxian   +3 more
doaj  

Temporal Interference Stimulation of Centromedian‐Parafascicular Complex in Disorders of Consciousness: A Pilot Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Treatment of disorders of consciousness (DoC) remains a major clinical challenge, and noninvasive, targeted modulation of deep brain structures has emerged as a promising therapeutic strategy. We aimed to evaluate the feasibility/safety and preliminary effects of thalamic temporal interference stimulation (TIS) targeting centromedian‐
Gengyao Hu, Changgeng Song, Dianwei Wu, Xiaoqian Niu, Jianmin Hao, Lijuan Liu, Xiaogang Kang, Wen Jiang   +7 more
wiley   +1 more source