Results 121 to 130 of about 13,517,481 (303)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Screw pull-out force predictions in porcine radii using efficient nonlinear µFE models including contact and pre-damage

Frontiers in Bioengineering and Biotechnology
Nonlinear micro finite element (µFE) models have become the gold-standard for accurate numerical modeling of bone-screw systems. However, the detailed representation of bone microstructure, along with the inclusion of nonlinear material and contact, and ...
Pia Stefanek, J. D. Silva-Henao, J. D. Silva-Henao, Victoria Fiedler, A. G. Reisinger, A. G. Reisinger, Dieter H. Pahr, Alexander Synek   +7 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Co-design of a natural fiber-timber hybrid structural system using dual-robot coreless filament winding

Scientific Reports
This paper presents the co-design methods for a new hybrid load-bearing system as a strategy for advancing bio-based architecture. Timber and natural fiber polymer composites (NFPC) are combined into a hybrid system, offering opportunities to leverage ...
Rebeca Duque Estrada, Fabian Kannenberg, Tzu-Ying Chen, Yanan Guo, Jan Knippers, Achim Menges   +5 more
doaj   +1 more source

A Flux-Guided Shape-Refinement Framework for Freeform Shells Toward Improved Directional Compatibility Under Gravity Loading

Applied Mechanics
This study presents a discrete–continuous flux-guided shape-refinement framework for freeform shell geometries under self-weight. The method evaluates the directional relation between a prescribed support-directed transmission field and the shell surface
Abtin Baghdadi, Harald Kloft
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Structural Timber Design to Eurocode 5

, 2013
Structural Timber Design to Eurocode 5 provides practising engineers and specialist contractors with comprehensive, detailed information and in-depth guidance on the design of timber structures based on the common rules and rules for buildings in ...
Kermani, Abdy, Porteous, Jack
core  

Design of an aluminium bicycle path integrated in a steel bridge

, 2007
This paper describes the design of the aluminium structure of a bicycle path which is mounted on an existing steel bridge. The benefits of aluminium, being low self weight, freedom in design obtained by extrusion and good corrosion resistance were ...
Soetens, F., Johan Maljaars, Soetens, F Frans, Maljaars, J., Frans Soetens, Maljaars, J Johan, Henco Burggraaf, Maljaars, J.; id_orcid, Burggraaf, H.G., Burggraaf, H   +9 more
core   +1 more source