Results 151 to 160 of about 4,022,588 (277)

Taming the Achilles' Heel: A Chemical and Structural Design to Address Off-Target Effects in siRNA Therapeutics. [PDF]

JACS Au
Parvathaneni RP, Krishnan N, Hempel N, Oommen OP, Varghese OP.   +4 more
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Composition and Structural Design of Magnetic Alloy/Composites for High-Performance Microwave Absorption: A Review. [PDF]

Nanomaterials (Basel)
Zhou M, Zhou Z, Cheng H.
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Structural Design and Performance Optimization of Proton Exchange Membranes for Water Electrolysis: A Review. [PDF]

Membranes (Basel)
Chen Y, Ma H, Hsiao BS.
europepmc   +1 more source

STAEBL: Structural tailoring of engine blades, phase 2 [PDF]

The Structural Tailoring of Engine Blades (STAEBL) program was initiated at NASA Lewis Research Center in 1980 to introduce optimal structural tailoring into the design process for aircraft gas turbine engine blades.
Brown, K. W., Hirschbein, M. S.
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

From Structural Design to Molecular Mechanisms: The Evolution of Solar Evaporators. [PDF]

Chem Bio Eng
Wu D, Zhu J, Zhang Q, Huang X, Nie Z.
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Features of the Structural Design of Welded Joints of Superelastic Nitinol Wires. [PDF]

Materials (Basel)
Kvasnytskyi V, Zvorykina A, Zvorykin L, Zvorykin C, Chvertko Y.   +4 more
europepmc   +1 more source