Results 31 to 40 of about 455,062 (267)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Impact Energy Absorption Behavior of Unequal Strength Liquid Storage Structures Under Drop Hammer Impact

Applied Sciences
To enhance the impact resistance and protective performance of ship double-bottom liquid tanks, a liquid storage structure with unequal panel strength was designed.
Zhenghan Chen, Yongqing Li, Dian Li, Hailiang Hou   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Study on Dynamic Response of Rockfall-Impacted Pile-Column Bridge Piers Based on Scaled Model Tests

Buildings
To investigate the structural dynamic response of pile-column bridge piers in mountainous regions under rockfall impact, this study takes the No. 4 double-column pier of Changba Bridge in Nanchuan, Chongqing, as a prototype.
Li-Ming Wu, Zi-Jian Wang, Yi Jiang, Jian Jiang, Hu-Xin-Tong Huang, Yu-Si Chen   +5 more
doaj   +1 more source

Effective sensor location for detection of change in structural dynamic response

Journal of Low Frequency Noise, Vibration and Active Control, 2023
This paper investigates the sensitivity of structural system response to the sensor location by investigating consequences of small changes in the location to the structural system response.
J Woodall, A Maji, F Moreu
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Structural Dynamic Response of a Shield Tunnel under Aircraft Taxiing Load

Shock and Vibration, 2021
Dynamic load is an important factor affecting the safety and stability of subway tunnel structures. To obtain the variation law of shield tunnel structure dynamic response under aircraft taxiing load, a three-dimensional numerical simulation of such ...
Zhanyou Luo, Kuangqin Xie, Baoping Zou, Mingyao Jiang, Wei Zheng   +4 more
doaj   +1 more source