Results 71 to 80 of about 458,192 (267)

Optimal Design of Structures under Impact Loading

Shock and Vibration, 1996
In the design process structural optimization is a useful tool to reach design decisions. The impact behavior of structures is important for many designs, such as for automobiles.
Uwe Schramm, Walter D. Pilkey
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Dynamic and static structural responses of the spent nuclear fuel disposal canister due to the accidental drop and impact on to the ground

Cogent Engineering, 2017
In this paper, dynamic and static structural responses of the spent nuclear fuel disposal canister for PWR due to the accidental drop and impact on to the ground are analyzed in a multidisciplinary analysis manner theoretically and numerically in order ...
Young Joo Kwon
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Structural dynamic response analysis of a reverse-flow pulse detonation combustor

Case Studies in Thermal Engineering
The reverse-flow pulse detonation combustor (PDC) effectively overcomes the excessive length issue of straight-tube detonation combustors, which restricts their engineering application.
Jing Xin, Zeng Han, Zheng Longxi, Lu Ling, Zhang Junli, Zhou Daoen, Tan Wenhao, Yang Yudong, Wang Dingding, Li Qing   +9 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Broadband Dynamic Sensitivity Analysis of a Euler–Bernoulli Beam Under Thermal Load Using the Efficient Wave-Based Method

Aerospace
Beam-type structures used in aerospace applications may experience simultaneous broadband dynamic excitation and thermal loads. Design sensitivity, as a powerful tool for structural optimization and reliability analysis, is investigated in this work. The
Xudong Zhang, Hao Tang, Hao Yan, Qiang Chen   +3 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Dynamic response of structures with uncertain parameters

IOP Conference Series: Materials Science and Engineering, 2010
In this paper, an interval method for the dynamic response of structures with uncertain parameters is presented. In the presented method, the structural physical and geometric parameters and loads can be considered as interval variables. The structural stiffness matrix, mass matrix and loading vectors are described as the sum of two parts corresponding
Z H Cai, Y W Yang, Y Liu
openaire   +1 more source