Results 181 to 190 of about 6,591,436 (258)

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Gα_s-specific structural elements attenuate interactions with regulator of G protein signaling (RGS) proteins. [PDF]

FEBS J
Higazy-Mreih S, Avital-Shacham M, LeGouill C, Bouvier M, Kosloff M.   +4 more
europepmc   +1 more source

Critical structural elements for the antigenicity of wheat allergen LTP1 (Tri a 14) revealed by site-directed mutagenesis. [PDF]

Sci Rep, 2022
Mameri H, Gaudin JC, Lollier V, Tranquet O, Brossard C, Pietri M, Marion D, Codreanu-Morel F, Beaudouin E, Wien F, Gohon Y, Briozzo P, Denery-Papini S.   +12 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Influence of Noble Metals on Morphology and Topology of Structural Elements in Magnesium Alloy. [PDF]

Materials (Basel)
Greshta VL, Shalomeev VA, Lukianenko OS, Bogucki R, Korniejenko K, Tabunshchyk SS.   +5 more
europepmc   +1 more source

Evolution of a chronic pain management program in a Northwestern Ontario community: from structural elements to practical application. [PDF]

BMC Health Serv Res, 2022
Shojaei H, Lakha SF, Lyon A, Halabecki M, Donaghy M, Mailis A.   +5 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Engineered Branaplam Aptamers Exploit Structural Elements from Natural Riboswitches. [PDF]

ACS Chem Biol
Mohsen MG, Midy MK, Balaji A, Breaker RR.   +3 more
europepmc   +1 more source

Modifications of mRNA vaccine structural elements for improving mRNA stability and translation efficiency. [PDF]

Mol Cell Toxicol, 2022
Kim SC, Sekhon SS, Shin WR, Ahn G, Cho BK, Ahn JY, Kim YH.   +6 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source