Results 81 to 90 of about 1,799,142 (294)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Parenting Stress, Mental Health, Dyadic Adjustment: A Structural Equation Model
Frontiers in Psychology, 2017 Objective: In the 1st year of the post-partum period, parenting stress, mental health, and dyadic adjustment are important for the wellbeing of both parents and the child.
Luca Rollè +17 more
doaj +1 more source
Human Capital Estimation through Structural Equation Models with some Categorical Observed Variables [PDF]
The aim of this paper is to estimate, for US, Canada and Italy, the latent variable human capital and its causal relationship with labor income, through some Structural Equation Models.
Di Bartolo, Annamaria
core
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Distance costs and Multinationals' foreign activities [PDF]
We derive a gravity equation from two general equilibrium models with multinational firms: a symmetric firm model where foreign affiliates rely on specific intermediate goods and a heterogenous firms model with country-specific fixed costs.
Kleinert, Jörn, Toubal, Farid
core
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
A structural equation model of reputational risk in South Africa
Cogent Economics & Finance, 2019 The central function of a bank inherently exposes it to various financial risks where each of these risks has the possibility to influence stakeholders’ perception.
SJ Ferreira, E. Redda, SH Dunga
doaj +1 more source
Użyteczność e-commerce w badaniach polskich użytkowników
Problemy Zarządzania, 2015 This paper concerns the usability of e-commerce. It presents the results of research both as a statistical description and in a model approach. The sample included 511 people.
Jarosław Banaś, Zbigniew Pastuszak
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source