Results 31 to 40 of about 188,629 (284)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Structural equation modeling in epidemiology

Cadernos de Saúde Pública
Structural equation modeling (SEM) is an important statistical tool for evaluating complex relations in several research areas. In epidemiology, the use and discussion of SEM have been limited thus far. This article presents basic principles and concepts
Leila Denise Alves Ferreira Amorim, Rosemeire L. Fiaccone, Carlos Antônio S. T. Santos, Tereza Nadya dos Santos, Lia Terezinha L. P. de Moraes, Nelson F. Oliveira, Silvano O. Barbosa, Darci Neves dos Santos, Letícia Marques dos Santos, Sheila M. A. Matos, Maurício L. Barreto   +10 more
doaj   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A MODIFIED UTAUT IN THE CONTEXT OF M-PAYMENT USAGE INTENTION IN MALAYSIA [PDF]

Journal of Applied Structural Equation Modeling, 2021
Kin Leong Tang, Nai Chiek Aik, Wei Lim Choong   +2 more
doaj   +1 more source

PREDICTING CONTINUANCE INTENTION AND USE OF MOBILE SHOPPING APPS WITH PLS-SEM AND NECESSARY CONDITION ANALYSIS IN TANDEM [PDF]

Journal of Applied Structural Equation Modeling
The adoption of multi-channel strategies by retailers, encompassing both online and offline modalities, has fundamentally transformed consumer shopping behaviors, resulting in a significant increase in mobile shopping.
Kin Leong Tang, Pei Meng Tan, Rae Hooi, Mei Peng Low, Kok Eng Tan, Kai Ching Yeo   +5 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

THE MEDIATING ROLE OF DRINKING MOTIVES ON THE LINK BETWEEN ALCOHOL USE AND PERSONALITY FACTORS [PDF]

Journal of Applied Structural Equation Modeling, 2023
Rachelle Ann A. Beninsig, Hersheys V. Calumpang, Ma. Olivia B. Espedion, Leandro R. De Luna   +3 more
doaj   +1 more source

THE MEDIATING ROLE OF GREEN IMAGE BETWEEN SOCIAL MEDIA ATTRIBUTES AND THE INTENTION TO REVISIT GREEN RESORTS [PDF]

Journal of Applied Structural Equation Modeling
This study aims to investigate social media attributes—including sharing of content, accessibility, and credibility—that can impact a tourist's intention to revisit green resorts.
Tak Jie Chan, Aminath Raushan Imad
doaj   +1 more source