Results 121 to 130 of about 623,007 (310)

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Acoustic emission in the determination of the structural integrity of concrete in buildings

, 1994
This report is discussed the acoustic emission in the determination of the structural integrity of concrte in buildings.RP 26 ...
Chan, Kin Seng., Broms, Bengt B., Yip, Woon Kwong.   +2 more
core  

Numerical analysis of the influence of a nearby fibre on the interface crack growth in composites under transverse tensile load

, 2016
In this paper the interface crack growth associated to the inter-fibre failure under tension is studied by means of a two-fibres BEM model. The influence of the presence of an undamaged secondary fibre on the evolution of the interface crack at a ...
París Carballo, Federico, Correa Montoto, Elena, Sandino de Benito, Carlos   +2 more
core   +1 more source

Ground Strength Test Technique of Variable-Camber Wing Leading Edge

Biomimetics
Morphing wing technology is crucial for enhancing the flight performance of aircraft. To address the monitoring challenges of full-scale variable-camber leading edges under flight conditions, this study introduces a ground-based strength testing ...
Shanshan Li, Xianmin Chen, Zhigang Wang, Yuanbo Liang   +3 more
doaj   +1 more source

Structural integrity [PDF]

Nature Medicine, 2005
openaire   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Post-Buckling Failure Mechanism and Optimal Tapered Termination Design for Composite Hat-Stiffened Panels

Aerospace
Composite hat-stiffened panels are widely used in civil aircraft structural design as typical closed-section stiffened components with high load-carrying efficiency.
Guofan Zhang, Chunhua Wan, Liang Chang, Xiaohua Nie   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Technical paper From: International Journal of Structural Integrity

, 2011
Peer ...
Oscoz, Mariluz Penalva, Zettler, Joachim, Papadopoulos, Michael P.   +2 more
core