Results 151 to 160 of about 3,878,602 (281)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Sustainable materials selection with emerging structural materials. [PDF]

Npj Mater Sustain
Burdett S, Arora M, Myers RJ.
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Laboratory Analysis of VOC Emissions from Structural Materials in Wildland-Urban Interface Fires. [PDF]

Environ Sci Technol
Dresser W, Ridgway K, Helfrich A, L'Orange C, Jathar S, de Gouw J.   +5 more
europepmc   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Ratcheting fatigue behaviour of advanced structural materials at their service temperatures. [PDF]

Sci Rep
Mishra P, Gupta V, Malwe PD, Urade A, Khanke V, Siddiqui MIH, Dixit S, Chan CK, Sonawane C, Tejani GG.   +9 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Editorial: Editors’ showcase: structural materials

Frontiers in Materials, 2023
John L. Provis, Xiangming Zhou
doaj   +1 more source

The Impact of Destructive Climatic Factors on the Mechanical and Performance Properties of Structural Materials. [PDF]

Materials (Basel)
Widomski P, Maksymowicz P, Trzaska O, Mayer-Trzaskowska P, Kaczyński P, Berbesz-Wyrodek A, Gronostajska B, Bober W, Kogut M.   +8 more
europepmc   +1 more source

Naturally architected microstructures in structural materials via additive manufacturing. [PDF]

Addit Manuf, 2020
Traxel KD, Bandyopadhyay A.
europepmc   +1 more source