Results 91 to 100 of about 4,198,362 (306)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Structural Mechanics of the Alpha-2-Macroglobulin Transformation. [PDF]
J Mol Biol, 2022 Arimura Y, Funabiki H.
europepmc +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Challenging Glass Conference Proceedings, 2018 Glass is an indispensable material in the building industry. The combination of transparency, strength and durability makes it to an unparalleled and desirable material. The technology additive manufacturing (AM) has a potential in the building industry,
Matthias Seel +5 more
doaj +1 more source
Fluid-structure interaction analysis of airflow, structural mechanics and aerosol dynamics in a four-generation acinar model. [PDF]
J Aerosol Sci, 2023 Li P, Guo W, Fan J, Su C, Zhao X, Xu X.
europepmc +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Analysis and modelization of lightweight structures subjected to impact [PDF]
, 2008 Mechanics of Advanced Materials research group (Department of Continuum Mechanics and Structural Analysis) of the University Carlos III of Madrid (Spain) offers their experience in the analysis and modelization of high and low velocity impact behaviour ...
Barbero Pozuelo, Enrique +1 more
core +1 more source
Measurements of 2-D flow parameters around rectangular prisms arranged at the ground
Budownictwo i Architektura, 2008 Measurements of 2-D flows around a square and a rectangle (ratio 2:1) in wind tunnel have been presented in this paper. The results of these measurements presented here are pressure and standard deviation distributions on the models’ walls, components of
Ewa Błazik-Borowa +4 more
doaj +1 more source
Special Issue: "Advances in Structural Mechanics Modeled with FEM". [PDF]
Materials (Basel), 2021 Tarantino AM +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source