Results 51 to 60 of about 4,198,362 (306)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Damage Detection with Data-Driven Machine Learning Models on an Experimental Structure

Eng
Various techniques have been employed to detect damage in civil engineering structures. Apart from the model-based approach, which demands the frequent updating of its corresponding finite element method (FEM)-built model, data-driven methods have gained
Yohannes L. Alemu, Tom Lahmer, Christian Walther   +2 more
doaj   +1 more source

Kinematic Modelling and Simulation of a 2-R Robot Using SolidWorks and Verification by MATLAB/Simulink

International Journal of Advanced Robotic Systems, 2012
The simulation of robot systems is becoming very popular, especially with the lowering of the cost of computers, and it can be used for layout evaluation, feasibility studies, presentations with animation and off-line programming. The trajectory planning
Mahmoud Gouasmi, Mohammed Ouali, Brahim Fernini, M'hamed Meghatria   +3 more
doaj   +1 more source

A Structure-Function Mechanism for Schizophrenia [PDF]

Frontiers in Psychiatry, 2012
THE MULTIPLE ETIOLOGIES OF SCHIZOPHRENIA PROMPT US TO RAISE THE QUESTION: what final common pathway can induce a convincing sense of the reality of the hallucinations in this disease? The observation that artificial stimulation of an intermediate order of neurons of a normal nervous system induces hallucinations indicates that the lateral entry of ...
openaire   +4 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Computational structural mechanics engine structures computational simulator [PDF]

, 1989
The Computational Structural Mechanics (CSM) program at Lewis encompasses: (1) fundamental aspects for formulating and solving structural mechanics problems, and (2) development of integrated software systems to computationally simulate the performance ...
Chamis, C. C.
core  

An Efficient Uncertainty Quantification Approach for Robust Design of Tuned Mass Dampers in Linear Structural Dynamics

Applied Sciences
The application of tuned mass dampers (TMDs) to high-rise buildings or slender bridges can significantly decrease the dynamical vibrations due to external excitation, such as wind or earthquake loads.
Thomas Most, Volkmar Zabel, Rohan Raj Das, Abridhi Khadka   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Performance Study of a Torsional Wave Sensor and Cervical Tissue Characterization

Sensors, 2017
A novel torsional wave sensor designed to characterize mechanical properties of soft tissues is presented in this work. Elastography is a widely used technique since the 1990s to map tissue stiffness. Moreover, quantitative elastography uses the velocity
Antonio Callejas, Antonio Gomez, Juan Melchor, Miguel Riveiro, Paloma Massó, Jorge Torres, Modesto T. López-López, Guillermo Rus   +7 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source