Results 171 to 180 of about 4,114,692 (310)

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Enhanced active learning Gaussian process metamodel for estimating the one-sided tail probability of nonlinear structural response. [PDF]

Sci Rep
Wang Y, Huang Y, Huang Y, Yin W.
europepmc   +1 more source

Some issues in numerical simulation of nonlinear structural response [PDF]

The development of commercial finite element software is addressed. This software provides practical tools that are used in an astonishingly wide range of engineering applications that include critical aspects of the safety evaluation of nuclear power ...
Hibbitt, H. D.
core   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Biochemical and Structural Response to Lenvatinib in Metastatic Parathyroid Carcinoma: Case Report. [PDF]

Clin Med Insights Endocrinol Diabetes
Rivera WA, Ramírez MJ, Román A.
europepmc   +1 more source

Time-resolved in situ visualization of the structural response of zeolites during catalysis. [PDF]

Nat Commun, 2020
Kang J, Carnis J, Kim D, Chung M, Kim J, Yun K, An G, Cha W, Harder R, Song S, Sikorski M, Robert A, Thanh NH, Lee H, Choi YN, Huang X, Chu YS, Clark JN, Song MK, Yoon KB, Robinson IK, Kim H.   +21 more
europepmc   +1 more source

Structural Changes in International Trade - Cause, Impact and Response [PDF]

The character of the structural changes in international trade, and the possibility that these might impact countries differently, has been a matter of great concern for many observers from the 1950s onwards.
Jan Fagerberg
core  

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Empirical Investigation of the Structural Response of Super-Span Soil-Steel Arches During Backfilling. [PDF]

Materials (Basel)
Kunecki B.
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source